A novel common variant in DCST2 is associated with length in early life and height in adulthood.

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Fältnamn	Indikatorer	Metadata
000		09769naa a2202161 4500
001		oai:gup.ub.gu.se/261471
003		SwePub
008		240528s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:miun-24414
009		oai:prod.swepub.kib.ki.se:130808568
024	7	a https://gup.ub.gu.se/publication/2614712 URI
024	7	a https://doi.org/10.1093/hmg/ddu5102 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-244142 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1308085682 URI
040		a (SwePub)gud (SwePub)miund (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a van der Valk, Ralf J P4 aut
245	1 0	a A novel common variant in DCST2 is associated with length in early life and height in adulthood.
264		c 2014-10-03
264	1	b Oxford University Press (OUP),c 2015
520		a Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650	7	a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
653		a Adaptor Proteins
653		a Signal Transducing
653		a genetics
653		a metabolism
653		a Adult
653		a Age Factors
653		a Alleles
653		a Body Height
653		a genetics
653		a Computational Biology
653		a Databases
653		a Genetic
653		a Genetic Association Studies
653		a Genetic Variation
653		a Genotype
653		a Humans
653		a Infant
653		a Newborn
653		a Membrane Proteins
653		a genetics
653		a metabolism
653		a Phenotype
653		a Polymorphism
653		a Single Nucleotide
653		a Quantitative Trait Loci
653		a Quantitative Trait
653		a Heritable
653		a Reproducibility of Results
700	1	a Kreiner-Møller, Eskil4 aut
700	1	a Kooijman, Marjolein N4 aut
700	1	a Guxens, Mònica4 aut
700	1	a Stergiakouli, Evangelia4 aut
700	1	a Sääf, Annika4 aut
700	1	a Bradfield, Jonathan P4 aut
700	1	a Geller, Frank4 aut
700	1	a Hayes, M Geoffrey4 aut
700	1	a Cousminer, Diana L4 aut
700	1	a Körner, Antje4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Curtin, John A4 aut
700	1	a Myhre, Ronny4 aut
700	1	a Huikari, Ville4 aut
700	1	a Joro, Raimo4 aut
700	1	a Kerkhof, Marjan4 aut
700	1	a Warrington, Nicole M4 aut
700	1	a Pitkänen, Niina4 aut
700	1	a Ntalla, Ioanna4 aut
700	1	a Horikoshi, Momoko4 aut
700	1	a Veijola, Riitta4 aut
700	1	a Freathy, Rachel M4 aut
700	1	a Teo, Yik-Ying4 aut
700	1	a Barton, Sheila J4 aut
700	1	a Evans, David Mu Karolinska Institutet4 aut
700	1	a Kemp, John P4 aut
700	1	a St Pourcain, Beate4 aut
700	1	a Ring, Susan M4 aut
700	1	a Davey Smith, George4 aut
700	1	a Bergström, Annau Karolinska Institutet4 aut
700	1	a Kull, Ingeru Karolinska Institutet4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Mentch, Frank D4 aut
700	1	a Bisgaard, Hans4 aut
700	1	a Chawes, Bo4 aut
700	1	a Stokholm, Jakob4 aut
700	1	a Waage, Johannes4 aut
700	1	a Eriksen, Patrick4 aut
700	1	a Sevelsted, Astrid4 aut
700	1	a Melbye, Mads4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Medina-Gomez, Carolina4 aut
700	1	a Hofman, Albert4 aut
700	1	a de Jongste, Johan C4 aut
700	1	a Taal, H Rob4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Armstrong, Loren L4 aut
700	1	a Eriksson, Johan4 aut
700	1	a Palotie, Aarno4 aut
700	1	a Bustamante, Mariona4 aut
700	1	a Estivill, Xavier4 aut
700	1	a Gonzalez, Juan R4 aut
700	1	a Llop, Sabrina4 aut
700	1	a Kiess, Wieland4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a Flexeder, Claudia4 aut
700	1	a Tiesler, Carla M T4 aut
700	1	a Murray, Clare S4 aut
700	1	a Simpson, Angela4 aut
700	1	a Magnus, Per4 aut
700	1	a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve
700	1	a Hartikainen, Anna-Liisa4 aut
700	1	a Keinanen-Kiukaanniemi, Sirkka4 aut
700	1	a Lewin, Alexandra4 aut
700	1	a Da Silva Couto Alves, Alexessander4 aut
700	1	a Blakemore, Alexandra I4 aut
700	1	a Buxton, Jessica L4 aut
700	1	a Kaakinen, Marika4 aut
700	1	a Rodriguez, Alinau Mittuniversitetet,Avdelningen för psykologi4 aut0 (Swepub:miun)alirod
700	1	a Sebert, Sylvain4 aut
700	1	a Vaarasmaki, Marja4 aut
700	1	a Lakka, Timo4 aut
700	1	a Lindi, Virpi4 aut
700	1	a Gehring, Ulrike4 aut
700	1	a Postma, Dirkje S4 aut
700	1	a Ang, Wei4 aut
700	1	a Newnham, John P4 aut
700	1	a Lyytikäinen, Leo-Pekka4 aut
700	1	a Pahkala, Katja4 aut
700	1	a Raitakari, Olli T4 aut
700	1	a Panoutsopoulou, Kalliope4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Boomsma, Dorret I4 aut
700	1	a Groen-Blokhuis, Maria4 aut
700	1	a Ilonen, Jorma4 aut
700	1	a Franke, Lude4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Pers, Tune H4 aut
700	1	a Liang, Liming4 aut
700	1	a Huang, Jinyan4 aut
700	1	a Hocher, Berthold4 aut
700	1	a Knip, Mikael4 aut
700	1	a Saw, Seang-Mei4 aut
700	1	a Holloway, John W4 aut
700	1	a Melén, Erik4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Lowe, William L4 aut
700	1	a Widén, Elisabeth4 aut
700	1	a Sergeyev, Elena4 aut
700	1	a Grallert, Harald4 aut
700	1	a Custovic, Adnan4 aut
700	1	a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Atalay, Mustafa4 aut
700	1	a Koppelman, Gerard H4 aut
700	1	a Pennell, Craig E4 aut
700	1	a Niinikoski, Harri4 aut
700	1	a Dedoussis, George V4 aut
700	1	a Mccarthy, Mark I4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Sunyer, Jordi4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Bønnelykke, Klaus4 aut
700	1	a Jaddoe, Vincent W V4 aut
710	2	a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t Human molecular geneticsd : Oxford University Press (OUP)g 24:4, s. 1155-68q 24:4<1155-68x 1460-2083x 0964-6906
856	4	u https://academic.oup.com/hmg/article-pdf/24/4/1155/14144121/ddu510.pdf
856	4	u https://doi.org/10.1093/hmg/ddu510y Fulltext
856	4	u https://miun.diva-portal.org/smash/get/diva2:790291/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://gup.ub.gu.se/publication/261471
856	4 8	u https://doi.org/10.1093/hmg/ddu510
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24414
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:130808568

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By the author/editor: van der Valk, Ra ...; Kreiner-Møller, ...; Kooijman, Marjol ...; Guxens, Mònica; Stergiakouli, Ev ...; Sääf, Annika; show more...; Bradfield, Jonat ...; Geller, Frank; Hayes, M Geoffre ...; Cousminer, Diana ...; Körner, Antje; Thiering, Elisab ...; Curtin, John A; Myhre, Ronny; Huikari, Ville; Joro, Raimo; Kerkhof, Marjan; Warrington, Nico ...; Pitkänen, Niina; Ntalla, Ioanna; Horikoshi, Momok ...; Veijola, Riitta; Freathy, Rachel ...; Teo, Yik-Ying; Barton, Sheila J; Evans, David M; Kemp, John P; St Pourcain, Bea ...; Ring, Susan M; Davey Smith, Geo ...; Bergström, Anna; Kull, Inger; Hakonarson, Hako ...; Mentch, Frank D; Bisgaard, Hans; Chawes, Bo; Stokholm, Jakob; Waage, Johannes; Eriksen, Patrick; Sevelsted, Astri ...; Melbye, Mads; van Duijn, Corne ...; Medina-Gomez, Ca ...; Hofman, Albert; de Jongste, Joha ...; Taal, H Rob; Uitterlinden, An ...; Armstrong, Loren ...; Eriksson, Johan; Palotie, Aarno; Bustamante, Mari ...; Estivill, Xavier; Gonzalez, Juan R; Llop, Sabrina; Kiess, Wieland; Mahajan, Anubha; Flexeder, Claudi ...; Tiesler, Carla M ...; Murray, Clare S; Simpson, Angela; Magnus, Per; Sengpiel, Verena ...; Hartikainen, Ann ...; Keinanen-Kiukaan ...; Lewin, Alexandra; Da Silva Couto A ...; Blakemore, Alexa ...; Buxton, Jessica ...; Kaakinen, Marika; Rodriguez, Alina; Sebert, Sylvain; Vaarasmaki, Marj ...; Lakka, Timo; Lindi, Virpi; Gehring, Ulrike; Postma, Dirkje S; Ang, Wei; Newnham, John P; Lyytikäinen, Leo ...; Pahkala, Katja; Raitakari, Olli ...; Panoutsopoulou, ...; Zeggini, Elefthe ...; Boomsma, Dorret ...; Groen-Blokhuis, ...; Ilonen, Jorma; Franke, Lude; Hirschhorn, Joel ...; Pers, Tune H; Liang, Liming; Huang, Jinyan; Hocher, Berthold; Knip, Mikael; Saw, Seang-Mei; Holloway, John W; Melén, Erik; Grant, Struan F ...; Feenstra, Bjarke; Lowe, William L; Widén, Elisabeth; Sergeyev, Elena; Grallert, Harald; Custovic, Adnan; Jacobsson, Bo, 1 ...; Jarvelin, Marjo- ...; Atalay, Mustafa; Koppelman, Gerar ...; Pennell, Craig E; Niinikoski, Harr ...; Dedoussis, Georg ...; Mccarthy, Mark I; Frayling, Timoth ...; Sunyer, Jordi; Timpson, Nichola ...; Rivadeneira, Fer ...; Bønnelykke, Klau ...; Jaddoe, Vincent ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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