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Palmgren, MadeleneGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
(author)
Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-09-15
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Springer Science and Business Media LLC,2017
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/261535
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https://gup.ub.gu.se/publication/261535URI
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https://doi.org/10.1007/s00232-017-9988-4DOI
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https://research.chalmers.se/publication/253846URI
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https://lup.lub.lu.se/record/ac75f839-7f22-4cf9-9b50-d903ef3c3398URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins. Using a newly established Nuclear Magnetic Resonance approach based on measurement of the intracellular life time of water, we propose that human aquaglyceroporins are poor facilitators of water and that the water transport efficiency is similar to that of passive diffusion across native cell membranes. This is distinctly different from glycerol and arsenic trioxide, where high glycerol transport efficiency was recorded.
Subject headings and genre
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Hernebring, Malin,1978Lunds universitet,Lund University(Swepub:gu)xhernm
(author)
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Eriksson, StefanieLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fkem-sfe
(author)
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Elbing, KarinLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)med-keg
(author)
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Geijer, Cecilia,1980Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:cth)cecgei
(author)
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Lasic, S.CR Development AB
(author)
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Dahl, Peter,1965Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xdapet
(author)
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Söndergaard Hansen, JesperLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)med-js_
(author)
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Topgaard, DanielLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fk1-dto
(author)
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Lindkvist-Petersson, KarinGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Lunds universitet,Lund University,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)mbfy-kpe
(author)
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Göteborgs universitetInstitutionen för kemi och molekylärbiologi
(creator_code:org_t)
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In:Journal of Membrane Biology: Springer Science and Business Media LLC250:6, s. 629-6390022-26311432-1424
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