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Evidence for a prim...
Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs.
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Flahou, Bram (author)
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Rossi, Mirko (author)
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Bakker, Jaco (author)
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Langermans, Jan Am (author)
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Heuvelman, Edwin (author)
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Solnick, Jay V (author)
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Martin, Miriam E (author)
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O'Rourke, Jani (author)
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Ngoan, Le Duc (author)
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Hoa, Nguyen Xuan (author)
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Nakamura, Masahiko (author)
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Øverby, Anders (author)
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Matsui, Hidenori (author)
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Ota, Hiroyoshi (author)
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Matsumoto, Takehisa (author)
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Foss, Dennis L (author)
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Kopta, Laurice A (author)
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Omotosho, Oladipo (author)
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Franciosini, Maria Pia (author)
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Casagrande Proietti, Patrizia (author)
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Guo, Aizhen (author)
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Liu, Han (author)
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Borilova, Gabriela (author)
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Bracarense, Ana Paula (author)
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- Lindén, Sara K., 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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De Bruyckere, Sofie (author)
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Zhang, Guangzhi (author)
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De Witte, Chloë (author)
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Smet, Annemieke (author)
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Pasmans, Frank (author)
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Ducatelle, Richard (author)
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Corander, Jukka (author)
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Haesebrouck, Freddy (author)
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(creator_code:org_t)
- 2017-09-08
- 2018
- English.
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In: The ISME journal. - : Springer Science and Business Media LLC. - 1751-7370 .- 1751-7362. ; 12:1, s. 77-86
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https://www.nature.c...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100000 and 15000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Flahou, Bram
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Rossi, Mirko
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Bakker, Jaco
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Langermans, Jan ...
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Heuvelman, Edwin
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Solnick, Jay V
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show more...
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Martin, Miriam E
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O'Rourke, Jani
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Ngoan, Le Duc
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Hoa, Nguyen Xuan
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Nakamura, Masahi ...
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Øverby, Anders
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Matsui, Hidenori
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Ota, Hiroyoshi
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Matsumoto, Takeh ...
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Foss, Dennis L
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Kopta, Laurice A
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Omotosho, Oladip ...
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Franciosini, Mar ...
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Casagrande Proie ...
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Guo, Aizhen
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Liu, Han
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Borilova, Gabrie ...
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Bracarense, Ana ...
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Lindén, Sara K., ...
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De Bruyckere, So ...
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Zhang, Guangzhi
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De Witte, Chloë
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Smet, Annemieke
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Pasmans, Frank
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Ducatelle, Richa ...
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Corander, Jukka
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Haesebrouck, Fre ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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The ISME journal
- By the university
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University of Gothenburg