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Disentangling the Effects of Serotonin on Risk Perception: S-Carriers of 5-HTTLPR Are Primarily Concerned With the Magnitude of the Outcomes, Not the Uncertainty

Millroth, Philip (author)
Uppsala universitet,Institutionen för psykologi
Juslin, Peter, 1964- (author)
Uppsala universitet,Institutionen för psykologi
Eriksson, Elias, 1956 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Ågren, Thomas (author)
Uppsala universitet,Institutionen för psykologi
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 (creator_code:org_t)
2017-10
2017
English.
In: Behavioral Neuroscience. - : American Psychological Association (APA). - 0735-7044 .- 1939-0084. ; 131:5, s. 421-427
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Serotonin signaling is vital for reward processing, and hence, also for decision-making. The serotonin transporter gene linked polymorphic region (5-HTTLPR) has been connected to decision making, suggesting that short-allele carriers (s) are more risk averse than long-allele homozygotes (ll). However, previous research has not identified if this occurs because s-carriers (i) are more sensitive to the uncertainty of the outcomes or (ii) are more sensitive to the magnitude of the outcomes. This issue was disentangled using a willingness-to-pay task, where the participants evaluated prospects involving certain gains, uncertain gains, and ambiguous gains. The results clearly favored the hypothesis that s-carriers react more to the magnitude of the outcomes. Self-reported measures of everyday risk-taking behavior also favored this hypothesis. We discuss how these results are in line with recent research on the serotonergic impact on reward processing.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)

Keyword

judgment and decision making
risk
5-HTTLPR
serotonin
reward processing
acute tryptophan depletion
dorsal raphe nucleus
transporter gene
decision-making
reward
polymorphism
ambiguity
amygdala
region
determinants
Behavioral Sciences
Neurosciences & Neurology
x cr
1995
quarterly journal of economics
v110
p585
Cognitive Processes

Publication and Content Type

ref (subject category)
art (subject category)

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Millroth, Philip
Juslin, Peter, 1 ...
Eriksson, Elias, ...
Ågren, Thomas
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
SOCIAL SCIENCES
SOCIAL SCIENCES
and Psychology
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Behavioral Neuro ...
By the university
University of Gothenburg
Uppsala University

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