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- Thornton, C. (author)
Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic-ischaemic brain injury
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-09-22
- Portland Press Ltd.2017
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- LIBRIS-ID:oai:gup.ub.gu.se/263360
- https://gup.ub.gu.se/publication/263360URI
- https://doi.org/10.1042/bst20170017DOI
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- Language:English
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- Birth asphyxia in term neonates affects 1-2/1000 live births and results in the development of hypoxic-ischaemic encephalopathy with devastating life-long consequences. The majority of neuronal cell death occurs with a delay, providing the potential of a treatment window within which to act. Currently, treatment options are limited to therapeutic hypothermia which is not universally successful. To identify new interventions, we need to understand the molecular mechanisms underlying the injury. Here, we provide an overview of the contribution of both oxidative stress and endoplasmic reticulum stress in the development of neonatal brain injury and identify current preclinical therapeutic strategies.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- nitric-oxide synthase
- unfolded protein response
- postresuscitation
- n-acetylcysteine
- dismutase transgenic mice
- electron-transport chain
- umbilical-cord occlusion
- cell-death
- reactive oxygen
- rat-brain
- mitochondrial dysfunction
- Biochemistry & Molecular Biology
Added entries (persons, corporate bodies, meetings, titles ...)
- Baburamani, A. A. (author)
- Kichev, A. (author)
- Hagberg, Henrik,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institutionen för neurovetenskap och fysiologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Institute of Neuroscience and Physiology(Swepub:gu)xhaghe (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)
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- In:Biochemical Society Transactions: Portland Press Ltd.45:5, s. 1067-10760300-51271470-8752
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