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Minimum Information...
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
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Fuchs, A. (author)
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Gliwinski, M. (author)
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Grageda, N. (author)
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show more...
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Spiering, R. (author)
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Abbas, A. K. (author)
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Appel, S. (author)
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Bacchetta, R. (author)
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Battaglia, M. (author)
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- Berglund, David, 1984- (author)
- Uppsala universitet,Klinisk immunologi
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Blazar, B. (author)
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Bluestone, J. A. (author)
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Bornhauser, M. (author)
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ten Brinke, A. (author)
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Brusko, T. M. (author)
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Cools, N. (author)
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Cuturi, M. C. (author)
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Geissler, E. (author)
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Giannoukakis, N. (author)
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Golab, K. (author)
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Hafler, D. A. (author)
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van Ham, S. M. (author)
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Hester, J. (author)
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Hippen, K. (author)
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Di Ianni, M. (author)
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Ilic, N. (author)
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Isaacs, J. (author)
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Issa, F. (author)
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Iwaszkiewicz-Grzes, D. (author)
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Jaeckel, E. (author)
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Joosten, I. (author)
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Klatzmann, D. (author)
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Koenen, H. (author)
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van Kooten, C. (author)
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- Korsgren, Olle (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Klinisk immunologi
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Kretschmer, K. (author)
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Levings, M. (author)
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Marek-Trzonkowska, N. M. (author)
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Martinez-Llordella, M. (author)
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Miljkovic, D. (author)
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Mills, K. H. G. (author)
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Miranda, J. P. (author)
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Piccirillo, C. A. (author)
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Putnam, A. L. (author)
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Ritter, T. (author)
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Roncarolo, M. G. (author)
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Sakaguchi, S. (author)
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Sanchez-Ramon, S. (author)
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Sawitzki, B. (author)
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Sofronic-Milosavljevic, L. (author)
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Sykes, M. (author)
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Tang, Q. Z. (author)
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Vives-Pi, M. (author)
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Waldmann, H. (author)
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Witkowski, P. (author)
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Wood, K. J. (author)
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Gregori, S. (author)
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Hilkens, C. M. U. (author)
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Lombardi, G. (author)
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Lord, P. (author)
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Martinez-Caceres, E. M. (author)
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Trzonkowski, P. (author)
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(creator_code:org_t)
- 2018-01-15
- 2018
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8
- Related links:
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https://www.frontier...
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Patobiologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Pathobiology (hsv//eng)
Keyword
- minimum information model
- T regulatory cells
- immunotherapy
- good manufacturing practice
- cell
- chimeric antigen receptor
- versus-host-disease
- adoptive transfer
- in-vitro
- transplantation
- blood
- expansion
- allograft
- tolerance
- therapies
- Immunology
- T regulatory cells
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Fuchs, A.
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Gliwinski, M.
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Grageda, N.
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Spiering, R.
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Abbas, A. K.
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Appel, S.
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show more...
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Bacchetta, R.
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Battaglia, M.
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Berglund, David, ...
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Blazar, B.
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Bluestone, J. A.
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Bornhauser, M.
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ten Brinke, A.
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Brusko, T. M.
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Cools, N.
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Cuturi, M. C.
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Geissler, E.
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Giannoukakis, N.
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Golab, K.
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Hafler, D. A.
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van Ham, S. M.
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Hester, J.
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Hippen, K.
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Di Ianni, M.
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Ilic, N.
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Isaacs, J.
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Issa, F.
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Iwaszkiewicz-Grz ...
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Jaeckel, E.
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Joosten, I.
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Klatzmann, D.
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Koenen, H.
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van Kooten, C.
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Korsgren, Olle
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Kretschmer, K.
-
Levings, M.
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Marek-Trzonkowsk ...
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Martinez-Llordel ...
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Miljkovic, D.
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Mills, K. H. G.
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Miranda, J. P.
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Piccirillo, C. A ...
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Putnam, A. L.
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Ritter, T.
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Roncarolo, M. G.
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Sakaguchi, S.
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Sanchez-Ramon, S ...
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Sawitzki, B.
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Sofronic-Milosav ...
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Sykes, M.
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Tang, Q. Z.
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Vives-Pi, M.
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Waldmann, H.
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Witkowski, P.
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Wood, K. J.
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Gregori, S.
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Hilkens, C. M. U ...
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Lombardi, G.
-
Lord, P.
-
Martinez-Caceres ...
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Trzonkowski, P.
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Pathobiology
- Articles in the publication
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Frontiers in Imm ...
- By the university
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University of Gothenburg
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Uppsala University