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More than a drainag...
More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue
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- Illes, Sebastian (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: Cerebrospinal Fluid in Neurologic Disorders. Handbook of Clinical Neurology. - : Elsevier. - 0072-9752. - 9780128042793 ; , s. 33-46
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Abstract
Subject headings
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- Current progress in neuroscience demonstrates that the brain is not an isolated organ and is influenced by the systemic environment and extracerebral processes within the body. In view of this new concept, blood and cerebrospinal fluid (CSF) are important body fluids linking extracerebral and intracerebral processes. For decades, substantial evidence has been accumulated indicating that CSF modulates brain states and influences behavior as well as cognition. This chapter provides an overview of how CSF directly modulates the function of different types of brain cells, such as neurons, neural stem cells, and CSF-contacting cells. Alterations in CSF content occur in most pathologic central nervous system (CNS) conditions. In a classic view, the function of CSF is to drain waste products and detrimental factors derived from diseased brain parenchyma. This chapter presents examples for how intra- and extracerebral pathologic processes lead to alterations in the CSF content. Current knowledge about how pathologically altered CSF influences the functionality of brain cells will be presented. Thereby, it becomes evident that CSF has more than a drainage function and has a causal role for the etiology and pathogenesis of different CNS diseases. © 2017 Elsevier B.V.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- adult neurogenesis
- brain aging
- CSF-contacting neurons
- dementia
- neuroautoimmune diseases
- neuronal electrophysiologic function
- traumatic brain injury
- volume transmission
- volume transmission-mediated encephalopathy
Publication and Content Type
- vet (subject category)
- kap (subject category)
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