Search: onr:"swepub:oai:gup.ub.gu.se/264382" > ECOdrug: A database...
Fältnamn | Indikatorer | Metadata |
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000 | 05483naa a2200853 4500 | |
001 | oai:gup.ub.gu.se/264382 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:cb16d738-c60b-4129-9a12-48256b9b81c5 | |
024 | 7 | a https://gup.ub.gu.se/publication/2643822 URI |
024 | 7 | a https://doi.org/10.1093/nar/gkx10242 DOI |
024 | 7 | a https://research.chalmers.se/publication/5003992 URI |
024 | 7 | a https://research.chalmers.se/publication/5003312 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Verbruggen, B.u University of Exeter4 aut |
245 | 1 0 | a ECOdrug: A database connecting drugs and conservation of their targets across species |
264 | c 2017-11-11 | |
264 | 1 | b Oxford University Press (OUP),c 2018 |
520 | a Pharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms. We introduce a new research platform tool, ECOdrug, that reliably connects drugs to their protein targets across divergent species. It harmonizes ortholog predictions from multiple sources via a simple user interface underpinning critical applications for a wide range of studies in pharmacology, ecotoxicology and comparative evolutionary biology. ECOdrug can be used to identify species with drug targets and identify drugs that interact with those targets. As such, it can be applied to support intelligent targeted drug safety testing by ensuring appropriate and relevant species are selected in ecological risk assessments. ECOdrug is freely accessible and available at: Http://www.ecodrug.org. © 2017 The Author(s). | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
653 | a atorvastatin | |
653 | a dexlansoprazole | |
653 | a esomeprazole | |
653 | a hydroxymethylglutaryl coenzyme A reductase inhibitor | |
653 | a mevinolin | |
653 | a omeprazole | |
653 | a rosuvastatin | |
653 | a accuracy | |
653 | a Article | |
653 | a Chlamydomonas reinhardtii | |
653 | a cholesterol synthesis | |
653 | a Daphnia | |
653 | a data analysis | |
653 | a drug database | |
653 | a drug efficacy | |
653 | a drug information | |
653 | a drug research | |
653 | a drug safety | |
653 | a drug screening | |
653 | a drug targeting | |
653 | a information processing | |
653 | a information retrieval | |
653 | a Lemna gibba | |
653 | a nonhuman | |
653 | a prediction | |
653 | a priority journal | |
653 | a protein targeting | |
653 | a reliability | |
653 | a toxicity testing | |
700 | 1 | a Gunnarsson, L.u University of Exeter4 aut |
700 | 1 | a Kristiansson, Erik,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)erikkr |
700 | 1 | a Österlund, Tobias,d 1984u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)tobiaso |
700 | 1 | a Owen, S. F.4 aut |
700 | 1 | a Snape, J. R.u The University of Warwick4 aut |
700 | 1 | a Tyler, C. R.u University of Exeter4 aut |
710 | 2 | a University of Exeterb Institutionen för matematiska vetenskaper4 org |
773 | 0 | t Nucleic Acids Researchd : Oxford University Press (OUP)g 46:D1q 46:D1x 0305-1048x 1362-4962 |
856 | 4 | u https://academic.oup.com/nar/article-pdf/46/D1/D930/23162040/gkx1024.pdf |
856 | 4 | u https://research.chalmers.se/publication/500331/file/500331_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/264382 |
856 | 4 8 | u https://doi.org/10.1093/nar/gkx1024 |
856 | 4 8 | u https://research.chalmers.se/publication/500399 |
856 | 4 8 | u https://research.chalmers.se/publication/500331 |
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