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- Lasar, D. (author)
Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- Elsevier BV,2018
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/264398
- https://gup.ub.gu.se/publication/264398URI
- https://doi.org/10.1016/j.celrep.2017.12.067DOI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPAR alpha, beta/delta, and gamma, respectively. We found that both PPARa and beta/delta are dispensable for brown fat function. In contrast, we could show that ablation of PPAR gamma in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by beta-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPAR gamma function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPAR gamma-mediated regulation of brown fat function and activation by b-adrenergic signaling.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- uncoupling protein-1 gene
- ppar-gamma
- adipose-tissue
- insulin-resistance
- white adipocytes
- energy-metabolism
- fat
- expression
- obesity
- alpha
- Cell Biology
- akrabarty k
- 1983
- journal of lipid research
- v24
- p381
Added entries (persons, corporate bodies, meetings, titles ...)
- Rosenwald, M. (author)
- Kiehlmann, E. (author)
- Balaz, M. (author)
- Tall, B. (author)
- Opitz, L. (author)
- Lidell, Martin,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xlidma (author)
- Zamboni, N. (author)
- Krznar, P. (author)
- Sun, W. F. (author)
- Varga, L. (author)
- Stefanicka, P. (author)
- Ukropec, J. (author)
- Nuutila, P. (author)
- Virtanen, K. (author)
- Amri, E. Z. (author)
- Enerbäck, Sven,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xenesv (author)
- Wahli, W. (author)
- Wolfrum, C. (author)
- Göteborgs universitetInstitutionen för biomedicin (creator_code:org_t)
Related titles
- In:Cell Reports: Elsevier BV22:3, s. 760-7732211-1247
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