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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03992naa a2200541 4500 | |
| 001 | oai:gup.ub.gu.se/264449 | |
| 003 | SwePub | |
| 008 | 240528s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2644492 URI |
| 024 | 7 | a https://doi.org/10.3389/fncel.2018.000192 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Anzabi, M.4 aut |
| 245 | 1 0 | a Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4 |
| 264 | c 2018-01-31 | |
| 264 | 1 | b Frontiers Media SA,c 2018 |
| 520 | a Despite successful management of ruptured intracranial aneurysm following subarachnoid hemorrhage (SAH), delayed cerebral ischemia (DCI) remains the main cause of high mortality and morbidity in patients who survive the initial bleeding. Astrocytes play a key role in neurovascular coupling. Therefore, changes in the neurovascular unit including astrocytes following SAH may contribute to the development of DCI and long-term complications. In this study, we characterized morphological changes in hippocampal astrocytes following experimental SAH, with special emphasis on glia-vascular cross-talk and hippocampal volume changes. Four days after induction of SAH or sham-operation in mice, their hippocampal volumes were determined by magnetic resonance imaging (MRI) and histological/stereological methods. Glial fibrillary acid protein (GFAP) immunostained hippocampal sections were examined by stereological techniques to detect differences in astrocyte morphology, and global spatial sampling method was used to quantify the length density of Aquaporin-4 (AQP4) positive capillaries. Our results indicated that hippocampal volume, as measured both by MRI and by histological approaches, was significantly lower in SAH animals than in the sham-operated group. Accordingly, in this animal model of SAH, hippocampal atrophy existed already at the time of DCI onset in humans. SAH induced retraction of GFAP positive astrocyte processes, accompanied by a significant reduction in the length density of AQP4 positive capillaries as well as narrowing of hippocampal capillaries. Meanwhile, astrocyte volume was higher in SAH mice compared with the sham-operated group. Morphological changes in hippocampal astrocytes seemingly disrupt glia-vascular interactions early after SAH and may contribute to hippocampal atrophy. We speculate that astrocytes and astrocyte-capillary interactions may provide targets for the development of therapies to improve the prognosis of SAH. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a astrocyte | |
| 653 | a aquaporin-4 | |
| 653 | a hippocampus | |
| 653 | a MRI | |
| 653 | a subarachnoid hemorrhage | |
| 653 | a water transport | |
| 653 | a k+ clearance | |
| 653 | a ion channels | |
| 653 | a brain | |
| 653 | a aquaporin-4 | |
| 653 | a mice | |
| 653 | a plasticity | |
| 653 | a edema | |
| 653 | a mislocalization | |
| 653 | a fractionator | |
| 653 | a NDLab | |
| 700 | 1 | a Ardalan, M.4 aut |
| 700 | 1 | a Iversen, N. K.4 aut |
| 700 | 1 | a Rafati, Ali H.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xhosal |
| 700 | 1 | a Hansen, B.4 aut |
| 700 | 1 | a Ostergaard, L.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Frontiers in Cellular Neuroscienced : Frontiers Media SAg 12q 12x 1662-5102 |
| 856 | 4 | u https://www.frontiersin.org/articles/10.3389/fncel.2018.00019/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/264449 |
| 856 | 4 8 | u https://doi.org/10.3389/fncel.2018.00019 |
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