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- Giese, A. K. (author)
Design and rationale for examining neuroimaging genetics in ischemic stroke The MRI-GENIE study
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-08-24
- Ovid Technologies (Wolters Kluwer Health),2017
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- LIBRIS-ID:oai:gup.ub.gu.se/265019
- https://gup.ub.gu.se/publication/265019URI
- https://doi.org/10.1212/nxg.0000000000000180DOI
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- Language:English
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- Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study.& para;& para;Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 international SiGN sites contributed MRIs of 3,301 patients with AIS. Detailed clinical phenotyping with the web-based Causative Classification of Stroke (CCS) system and genome-wide genotyping data were available for all participants. Neuroimaging analyses include the manual and automated assessments of established MRI markers. A high-throughput MRI analysis pipeline for the automated assessment of cerebrovascular lesions on clinical scans will be developed in a subset of scans for both acute and chronic lesions, validated against gold standard, and applied to all available scans. The extracted neuroimaging phenotypes will improve characterization of acute and chronic cerebrovascular lesions in ischemic stroke, including CCS subtypes, and their effect on functional outcomes after stroke. Moreover, genetic testing will uncover variants associated with acute and chronic MRI manifestations of cerebrovascular disease.& para;& para;Conclusions: The MRI-GENIE study aims to develop, validate, and distribute the MRI analysis platform for scans acquired as part of clinical care for patients with AIS, which will lead to (1) novel genetic discoveries in ischemic stroke, (2) strategies for personalized stroke risk assessment, and (3) personalized stroke outcome assessment.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- genome-wide association
- white-matter hyperintensities
- metastroke
- collaboration
- disease
- classification
- metaanalysis
- subtypes
- scale
- sign
- Neurosciences & Neurology
- CCAI 2014
- PT II17th International Conference on Medical Image Computing and Computer-Assisted
Added entries (persons, corporate bodies, meetings, titles ...)
- Schirmer, M. D. (author)
- Donahue, K. L. (author)
- Cloonan, L. (author)
- Irie, R. (author)
- Winzeck, S. (author)
- Bouts, Mjrj (author)
- McIntosh, E. C. (author)
- Mocking, S. J. (author)
- Dalca, A. V. (author)
- Sridharan, R. (author)
- Xu, H. C. (author)
- Frid, P. (author)
- Giralt-Steinhauer, E. (author)
- Holmegaard, LukasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xhollu (author)
- Roquer, J. (author)
- Wasselius, J. (author)
- Cole, J. W. (author)
- McArdle, P. F. (author)
- Broderick, J. P. (author)
- Jimenez-Conde, J. (author)
- Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xjerch (author)
- Kissela, B. M. (author)
- Kleindorfer, D. O. (author)
- Lemmens, R. (author)
- Lindgren, A. (author)
- Meschia, J. F. (author)
- Rundek, T. (author)
- Sacco, R. L. (author)
- Schmidt, R. (author)
- Sharma, P. (author)
- Slowik, A. (author)
- Thijs, V. (author)
- Woo, D. (author)
- Worrall, B. B. (author)
- Kittner, S. J. (author)
- Mitchell, B. D. (author)
- Rosand, J. (author)
- Golland, P. (author)
- Wu, O. (author)
- Rost, N. S. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
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- In:Neurology-Genetics: Ovid Technologies (Wolters Kluwer Health)3:52376-7839
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- Bouts, Mjrj
- McIntosh, E. C.
- Mocking, S. J.
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- Schmidt, R.
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- Slowik, A.
- Thijs, V.
- Woo, D.
- Worrall, B. B.
- Kittner, S. J.
- Mitchell, B. D.
- Rosand, J.
- Golland, P.
- Wu, O.
- Rost, N. S.
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