Search: onr:"swepub:oai:gup.ub.gu.se/265422" >
Sense-antisense lnc...
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Mondal, Tanmoy,1981University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
(author)
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis
- Article/chapterEnglish2018
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LIBRIS-ID:oai:gup.ub.gu.se/265422
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https://gup.ub.gu.se/publication/265422URI
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https://doi.org/10.1016/j.ccell.2018.01.020DOI
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https://lup.lub.lu.se/record/386a4d46-dfda-40ed-bb00-adcd85c135fdURI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137815258URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies.
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Juvvuna, Prasanna KumarUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xjuvpr
(author)
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Kirkeby, AgneteLund University,Lunds universitet,Human neural utvecklingsbiologi,Forskargrupper vid Lunds universitet,Human Neural Developmental Biology,Lund University Research Groups,University of Copenhagen(Swepub:lu)med-agk
(author)
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Mitra, SanhitaUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xmitsa
(author)
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Kosalai, Subazini Thankaswamy,1980University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xthans
(author)
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Traxler, LarissaLund University
(author)
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Hertwig, FalkUniversity of Cologne,University Hospital of Cologne,Charité - University Medicine Berlin(Swepub:lu)med-fah
(author)
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Wernig-Zorc, SaraUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xwersa
(author)
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Miranda, CarolineUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xmirca
(author)
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Deland, LilyUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy(Swepub:gu)xdelal
(author)
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Bartenhagen, ChristophUniversity Hospital of Cologne
(author)
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Volland, RuthUniversity Hospital of Cologne
(author)
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Bartsch, DenizUniversity of Cologne
(author)
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Bandaru, SashidarUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xbands
(author)
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Engesser, AnneUniversity Hospital of Cologne
(author)
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Subhash, Santhilal,1987University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xsubsa
(author)
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Martinsson, Tommy,1956University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology(Swepub:gu)xmarto
(author)
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Carén, Helena,1979University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xcareh
(author)
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Akyürek, Levent,1966University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Pathology,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xakyle
(author)
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Kurian, LeoUniversity of Cologne
(author)
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Kanduri, Meena,1974University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine(Swepub:gu)xkanme
(author)
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Huarte, MaiteSpanish Center for Biomedical Research Network in Oncology (CIBERONC)
(author)
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Kogner, PerKarolinska Institutet
(author)
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Fischer, MatthiasUniversity Hospital of Cologne
(author)
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Kanduri, Chandrasekhar,1967Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xchaka
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
(creator_code:org_t)
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In:Cancer Cell: Elsevier BV33:31535-61081878-3686
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