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Overexpression of p...
Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish
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Muller-Deile, J. (author)
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Schroder, P. (author)
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Beverly-Staggs, L. (author)
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Hiss, R. (author)
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Fiedler, J. (author)
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- Nyström, Jenny, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Thum, T. (author)
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Haller, H. (author)
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Schiffer, M. (author)
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(creator_code:org_t)
- 2018-02-26
- 2018
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
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https://doi.org/10.1...
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Abstract
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- So far the pathomechanism of preeclampsia in pregnancy is focussed on increased circulating levels of soluble fms-like tyrosin kinase-1 (sFLT-1) that neutralizes glomerular VEGF-A expression and prevents its signaling at the glomerular endothelium. As a result of changed glomerular VEGF-A levels endotheliosis and podocyte foot process effacement are typical morphological features of preeclampsia. Recently, microRNA-26a-5p (miR-26a-5p) was described to be also upregulated in the preeclamptic placenta. We found that miR-26a-5p targets VEGF-A expression by means of PIK3C2a in cultured human podocytes and that miR-26a-5p overexpression in zebrafish causes proteinuria, edema, glomerular endotheliosis and podocyte foot process effacement. Interestingly, recombinant zebrafish Vegf-Aa protein could rescue glomerular changes induced by miR-26a-5p. In a small pilot study, preeclamptic patients with podocyte damage identified by podocyturia, expressed significantly more urinary miR-26a-5p compared to healthy controls. Thus, functional and ultrastructural glomerular changes after miR-26a-5p overexpression can resemble the findings seen in preeclampsia and indicate a potential pathophysiological role of miR-26a-5p in addition to sFLT-1 in this disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- endothelial growth-factor
- vegf-a
- actin reorganization
- cell-migration
- expression
- angiogenesis
- pregnancies
- receptors
- podocytes
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Muller-Deile, J.
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Schroder, P.
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Beverly-Staggs, ...
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Hiss, R.
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Fiedler, J.
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Nyström, Jenny, ...
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show more...
-
Thum, T.
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Haller, H.
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Schiffer, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg