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Finasteride treatme...
Finasteride treatment and male breast cancer: a register-based cohort study in four Nordic countries
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Meijer, M. (author)
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Thygesen, L. C. (author)
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Green, A. (author)
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Emneus, M. (author)
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Brasso, K. (author)
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Iversen, P. (author)
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Pukkala, E. (author)
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- Bolin, Kristian (author)
- Gothenburg University,Göteborgs universitet,Institutionen för nationalekonomi med statistik,Centrum för hälsoekonomi (CHEGU),Department of Economics,Centre for Health Economics
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Stavem, K. (author)
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Ersboll, A. K. (author)
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(creator_code:org_t)
- 2017-12-13
- 2018
- English.
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 7:1, s. 254-260
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A potential link has been suggested between dispensed finasteride and increased risk of male breast cancer (MBC). Due to the rare occurrence of MBC, it remains to be established if such a relationship exists. The purpose of this study was to combine nationwide registers in four countries to assess the potential association between dispensed finasteride and MBC. A cohort of all males with dispensed finasteride in Denmark, Finland, Norway, and Sweden (1,365,088 person years) was followed up for up to 15years for breast cancer, and compared to a cohort of males unexposed to finasteride. Individual-level register data included country, dates of dispensed finasteride, MBC diagnosis, and death. Incidence rate ratios (IRRs) were estimated using a generalized linear model with a Poisson distribution. An increased risk of MBC was found among finasteride users (IRR=1.44, 95% confidence interval [95% CI]=1.11-1.88) compared to nonusers. The IRR increased to 1.60 (95% CI=1.20-2.13) when users in Norway and Sweden with short follow-up time were excluded. The highest IRR was seen among men with medium duration of dispensed finasteride, medium accumulated consumption of finasteride, and among men with first dispensed finasteride prescription 1-3years prior to diagnosis. The analyses suggested possible ascertainment bias and did not support a clear relationship between dispensed finasteride and MBC. In conclusion, a significant association between dispensed finasteride and MBC was identified. However, due to limited data for adjustment of potential confounding and surveillance bias in the present study, further research is needed to confirm these results.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast neoplasms male
- finasteride
- Nordic countries
- pharmacoepidemiology
- prostatic neoplasms
- benign prostatic hyperplasia
- 5-alpha-reductase inhibitors
- risk-factors
- therapy
- epidemiology
- diagnosis
- men
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Meijer, M.
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Thygesen, L. C.
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Green, A.
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Emneus, M.
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Brasso, K.
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Iversen, P.
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show more...
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Pukkala, E.
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Bolin, Kristian
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Stavem, K.
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Ersboll, A. K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Medicine
- By the university
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University of Gothenburg