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Congenital Zika vir...
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
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- Waldorf, Kristina M. Adams (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Nelson, B. R. (author)
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Stencel-Baerenwald, J. E. (author)
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Studholme, C. (author)
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Kapur, R. P. (author)
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Armistead, B. (author)
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Walker, C. L. (author)
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Merillat, S. (author)
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Vornhagen, J. (author)
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Tisoncik-Go, J. (author)
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Baldessari, A. (author)
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Coleman, M. (author)
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Dighe, M. K. (author)
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Shaw, D. W. W. (author)
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Roby, J. A. (author)
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Santana-Ufret, V. (author)
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Boldenow, E. (author)
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Li, J. W. (author)
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Gao, X. H. (author)
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Davis, M. A. (author)
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Swanstrom, J. A. (author)
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Jensen, K. (author)
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Widman, D. G. (author)
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Baric, R. S. (author)
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Medwid, J. T. (author)
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Hanley, K. A. (author)
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Ogle, J. (author)
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Gough, G. M. (author)
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Lee, W. (author)
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English, C. (author)
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Durning, W. M. (author)
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Thiel, J. (author)
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Gatenby, C. (author)
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Dewey, E. C. (author)
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Fairgrieve, M. R. (author)
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Hodge, R. D. (author)
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Grant, R. F. (author)
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Kuller, L. (author)
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Dobyns, W. B. (author)
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Hevner, R. F. (author)
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Gale, M. (author)
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Rajagopal, L. (author)
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(creator_code:org_t)
- 2018-02-05
- 2018
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 24:3, s. 368-374
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of ZIKV infection, we demonstrate that ZIKV-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. A common and subtle injury pattern was identified, including (i) periventricular T2-hyperintense foci and loss of fetal noncortical brain volume, (ii) injury to the ependymal epithelium with underlying gliosis and (iii) loss of late fetal neuronal progenitor cells in the subventricular zone (temporal cortex) and subgranular zone (dentate gyrus, hippocampus) with dysmorphic granule neuron patterning. Attenuation of fetal neurogenic output demonstrates potentially considerable teratogenic effects of congenital ZIKV infection even without microcephaly. Our findings suggest that all children exposed to ZIKV in utero should receive long-term monitoring for neurocognitive deficits, regardless of head size at birth.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- antibody-dependent enhancement
- neural stem-cells
- dengue virus
- adult
- brain
- progenitors
- immunity
- vaccine
- humans
- primate
- neurons
- Biochemistry & Molecular Biology
- Cell Biology
- Research & Experimental
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Waldorf, Kristin ...
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Nelson, B. R.
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Stencel-Baerenwa ...
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Studholme, C.
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Kapur, R. P.
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Armistead, B.
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show more...
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Walker, C. L.
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Merillat, S.
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Vornhagen, J.
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Tisoncik-Go, J.
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Baldessari, A.
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Coleman, M.
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Dighe, M. K.
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Shaw, D. W. W.
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Roby, J. A.
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Santana-Ufret, V ...
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Boldenow, E.
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Li, J. W.
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Gao, X. H.
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Davis, M. A.
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Swanstrom, J. A.
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Jensen, K.
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Widman, D. G.
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Baric, R. S.
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Medwid, J. T.
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Hanley, K. A.
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Ogle, J.
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Gough, G. M.
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Lee, W.
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English, C.
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Durning, W. M.
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Thiel, J.
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Gatenby, C.
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Dewey, E. C.
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Fairgrieve, M. R ...
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Hodge, R. D.
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Grant, R. F.
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Kuller, L.
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Dobyns, W. B.
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Hevner, R. F.
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Gale, M.
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Rajagopal, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Medicine
- By the university
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University of Gothenburg