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Integrative Persona...
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss
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- Piening, B. D. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Zhou, W. Y. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Contrepois, K. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Rost, H. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Gu Urban, Gucci Jijuan, 1984- (author)
- Uppsala universitet,Molekylära verktyg,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Mishra, T. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Hanson, B. M. (author)
- The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
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- Bautista, E. J. (author)
- The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA; Corp Invest & Agr Corpoica, Ctr Invest Tibaitata, Mosquera, Colombia
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- Leopold, S. (author)
- Stanford University,Jackson Lab Genom Med, Farmington, CT, USA
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- Yeh, C. Y. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA; Stanford Univ, Dept Radiol, Sch Med, Stanford, CA, USA; Stanford Univ, Canary Ctr Stanford, Sch Med, Stanford, CA, USA; Stanford Univ, Biomed Informat Program, Sch Med, Stanford, CA, USA,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
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- Spakowicz, D. (author)
- The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
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- Banerjee, I. (author)
- Stanford University,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA
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- Zhang, Cheng (author)
- KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
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- Kukurba, K. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Perelman, D. (author)
- Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
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Craig, C. (author)
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- Colbert, E. (author)
- Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
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- Salins, D. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Rego, S. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Lee, S. (author)
- Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
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Zhang, C. (author)
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- Wheeler, J. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Sailani, M. R. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Liang, L. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
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- Abbott, C. (author)
- Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Gerstein, M. (author)
- Yale University,Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA; Yale Univ, Dept Comp Sci, New Haven, CT, USA; Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT, USA
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- Mardinoglu, Adil, 1982 (author)
- Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),Chalmers tekniska högskola,Chalmers University of Technology,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden; Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden
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- Smith, Ulf, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden
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Rubin, D. L. (author)
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- Pitteri, S. (author)
- Stanford University,Stanford Univ, Dept Radiol, Sch Med, Stanford, CA, USA; Stanford Univ, Canary Ctr Stanford, Sch Med, Stanford, CA, USA,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
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- Sodergren, E. (author)
- The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
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McLaughlin, T. L. (author)
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- Weinstock, G. M. (author)
- Jackson Lab Genom Med, Farmington, CT, USA
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Snyder, M. P. (author)
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- Weinstock, Christof (author)
- The Jackson Laboratory for Genomic Medicine
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cell Systems. - : Elsevier BV. - 2405-4712 .- 2405-4720. ; 6:2
- Related links:
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http://www.cell.com/...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Advances in omics technologies now allow an unprecedented level of phenotyping for human diseases, including obesity, in which individual responses to excess weight are heterogeneous and unpredictable. To aid the development of better understanding of these phenotypes, we performed a controlled longitudinal weight perturbation study combining multiple omics strategies (genomics, transcriptomics, multiple proteomics assays, metabolomics, and microbiomics) during periods of weight gain and loss in humans. Results demonstrated that: (1) weight gain is associated with the activation of strong inflammatory and hypertrophic cardiomyopathy signatures in blood; (2) although weight loss reverses some changes, a number of signatures persist, indicative of long-term physiologic changes; (3) we observed omics signatures associated with insulin resistance that may serve as novel diagnostics; (4) specific biomolecules were highly individualized and stable in response to perturbations, potentially representing stable personalized markers. Most data are available open access and serve as a valuable resource for the community.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- high-fat diet
- mediated glucose disposal
- insulin suppression test
- adipose-cell size
- large gene lists
- gut microbiota
- subclinical
- inflammation
- akkermansia-muciniphila
- oxalobacter-formigenes
- metabolic
- syndrome
- Biochemistry & Molecular Biology
- Cell Biology
- type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Piening, B. D.
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Zhou, W. Y.
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Contrepois, K.
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Rost, H.
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Gu Urban, Gucci ...
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Mishra, T.
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show more...
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Hanson, B. M.
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Bautista, E. J.
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Leopold, S.
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Yeh, C. Y.
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Spakowicz, D.
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Banerjee, I.
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Zhang, Cheng
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Kukurba, K.
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Perelman, D.
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Craig, C.
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Colbert, E.
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Salins, D.
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Rego, S.
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Lee, S.
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Zhang, C.
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Wheeler, J.
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Sailani, M. R.
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Liang, L.
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Abbott, C.
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Gerstein, M.
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Mardinoglu, Adil ...
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Smith, Ulf, 1943
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Rubin, D. L.
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Pitteri, S.
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Sodergren, E.
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McLaughlin, T. L ...
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Weinstock, G. M.
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Snyder, M. P.
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Weinstock, Chris ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Systems
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Royal Institute of Technology
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Uppsala University