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Group B streptococc...
Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection
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Vornhagen, J. (author)
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Armistead, B. (author)
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Santana-Ufret, V. (author)
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Gendrin, C. (author)
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Merillat, S. (author)
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Coleman, M. (author)
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Quach, P. (author)
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Boldenow, E. (author)
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Alishetti, V. (author)
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Leonhard-Melief, C. (author)
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Ngo, L. Y. (author)
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Whidbey, C. (author)
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Doran, K. S. (author)
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Curtis, C. (author)
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- Waldorf, Kristina M. Adams (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Nance, E. (author)
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Rajagopal, L. (author)
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(creator_code:org_t)
- 2018-04-09
- 2018
- English.
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In: Journal of Clinical Investigation. - : American Society for Clinical Investigation. - 0021-9738 .- 1558-8238. ; 128:5, s. 1985-1999
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http://www.jci.org/a...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Thirteen percent of pregnancies result in preterm birth or stillbirth, accounting for fifteen million preterm births and three and a half million deaths annually. A significant cause of these adverse pregnancy outcomes is in utero infection by vaginal microorganisms. To establish an in utero infection, vaginal microbes enter the uterus by ascending infection; however, the mechanisms by which this occurs are unknown. Using both in vitro and murine models of vaginal colonization and ascending infection, we demonstrate how a vaginal microbe, group B streptococcus (GBS), which is frequently associated with adverse pregnancy outcomes, uses vaginal exfoliation for ascending infection. GBS induces vaginal epithelial exfoliation by activation of integrin and beta-catenin signaling. However, exfoliation did not diminish GBS vaginal colonization as reported for other vaginal microbes. Rather, vaginal exfoliation increased bacterial dissemination and ascending GBS infection, and abrogation of exfoliation reduced ascending infection and improved pregnancy outcomes. Thus, for some vaginal bacteria, exfoliation promotes ascending infection rather than preventing colonization. Our study provides insight into mechanisms of ascending infection by vaginal microbes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- uropathogenic escherichia-coli
- squamous-cell carcinoma
- mesenchymal
- transition
- preterm birth
- maternal colonization
- lipoteichoic acid
- anticancer drugs
- neonatal disease
- in-vivo
- expression
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Vornhagen, J.
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Armistead, B.
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Santana-Ufret, V ...
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Gendrin, C.
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Merillat, S.
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Coleman, M.
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show more...
-
Quach, P.
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Boldenow, E.
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Alishetti, V.
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Leonhard-Melief, ...
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Ngo, L. Y.
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Whidbey, C.
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Doran, K. S.
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Curtis, C.
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Waldorf, Kristin ...
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Nance, E.
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Rajagopal, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Journal of Clini ...
- By the university
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University of Gothenburg