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Acute exercise remo...
Acute exercise remodels promoter methylation in human skeletal muscle
- Article/chapterEnglish2012
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LIBRIS-ID:oai:gup.ub.gu.se/268036
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https://gup.ub.gu.se/publication/268036URI
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https://doi.org/10.1016/j.cmet.2012.01.001DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124231716URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle. We determined whether DNA methylation plays a role in exercise-induced gene expression. Whole genome methylation was decreased in skeletal muscle biopsies obtained from healthy sedentary men and women after acute exercise. Exercise induced a dose-dependent expression of PGC-1alpha, PDK4, and PPAR-delta, together with a marked hypomethylation on each respective promoter. Similarly, promoter methylation of PGC-1alpha, PDK4, and PPAR-delta was markedly decreased in mouse soleus muscles 45 min after ex vivo contraction. In L6 myotubes, caffeine exposure induced gene hypomethylation in parallel with an increase in the respective mRNA content. Collectively, our results provide evidence that acute gene activation is associated with a dynamic change in DNA methylation in skeletal muscle and suggest that DNA hypomethylation is an early event in contraction-induced gene activation.
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Yan, J.
(author)
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Egan, B.Karolinska Institutet
(author)
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Treebak, J. T.
(author)
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Rasmussen, M.
(author)
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Fritz, T.
(author)
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Caidahl, Kenneth,1949Karolinska Institutet,Gothenburg University,Göteborgs universitet,Extern,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,External,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcaike
(author)
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Krook, A.Karolinska Institutet
(author)
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O'Gorman, D. J.
(author)
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Zierath, J. R.Karolinska Institutet
(author)
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Karolinska InstitutetExtern
(creator_code:org_t)
Related titles
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In:Cell Metabolism: Elsevier BV15:3, s. 405-111550-41311932-7420
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- By the author/editor
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Barres, R.
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Yan, J.
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Egan, B.
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Treebak, J. T.
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Rasmussen, M.
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Fritz, T.
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Caidahl, Kenneth ...
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Krook, A.
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O'Gorman, D. J.
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Zierath, J. R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Cell Metabolism
- By the university
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University of Gothenburg
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Karolinska Institutet