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Testosterone is an endogenous regulator of BAFF and splenic B cell number

Wilhelmson, Anna S K (author)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberg Laboratory,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Lantero Rodriguez, Marta (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
Stubelius, Alexandra, 1983 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Fogelstrand, Per, 1971 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
Johansson, Inger, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Wallenberg Laboratory
Buechler, M. B. (author)
Lianoglou, S. (author)
Kapoor, V. N. (author)
Johansson, Maria E, 1977 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
Fagman, Johan Bourghardt, 1980 (author)
Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
Duhlin, A. (author)
Karolinska Institutet
Tripathi, P. (author)
Camponeschi, Alessandro (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
Porse, B. T. (author)
Rolink, A. G. (author)
Nissbrandt, Hans, 1952 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
Turley, S. J. (author)
Carlsten, Hans, 1954 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Mårtensson, Inga-Lill, 1957 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
Karlsson, M. C. I. (author)
Karolinska Institutet
Tivesten, Åsa, 1969 (author)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Wallenberg Laboratory,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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 (creator_code:org_t)
Springer Science and Business Media LLC, 2018
2018
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibro-blastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an alpha-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Keyword

levels inversely correlate
androgen receptor
immunological features
klinefelters-syndrome
tyrosine-hydroxylase
systemic-lupus
murine
lupus
sex-hormone
male-mice
homeostasis

Publication and Content Type

ref (subject category)
art (subject category)

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