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Elevated Urine Leve...
Elevated Urine Levels of Macrophage Migration Inhibitory Factor in Inflammatory Bladder Conditions: A Potential Biomarker for a Subgroup of Interstitial Cystitis/Bladder Pain Syndrome Patients
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Vera, P. L. (author)
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Preston, D. M. (author)
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Moldwin, R. M. (author)
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Erickson, D. R. (author)
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Mowlazadeh, B. (author)
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Ma, F. (author)
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Kouzoukas, D. E. (author)
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Meyer-Siegler, K. L. (author)
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- Fall, Magnus, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Urology. - : Elsevier BV. - 0090-4295. ; 116, s. 55-61
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE To investigate whether urinary levels of macrophage migration inhibitory factor (MIF) are elevated in interstitial cystitis/bladder pain syndrome (IC/BPS) patients with Hunner lesions and also whether urine MIF is elevated in other forms of inflammatory cystitis. METHODS Urine samples were assayed for MIF by enzyme-linked immunosorbent assay. Urine samples from 3 female groups were examined: IC/BPS patients without (N = 55) and with Hunner lesions (N = 43), and non-IC/BPS patients (N = 100; control group; no history of IC/BPS; cancer or recent bacterial cystitis). Urine samples from 3 male groups were examined: patients with bacterial cystitis (N = 50), radiation cystitis (N = 18) and noncystitis patients (N = 119; control group; negative for bacterial cystitis). RESULTS Urine MIF (mean MIF pg/mL +/- standard error of the mean) was increased in female IC/BPS patients with Hunner lesions (2159 +/- 435.3) compared with IC/BPS patients without Hunner lesions (460 +/- 114.5) or non-IC/BPS patients (414 +/- 47.6). Receiver operating curve analyses showed that urine MIF levels discriminated between the 2 IC groups (area under the curve = 72%; confidence interval 61%-82%). Male patients with bacterial and radiation cystitis had elevated urine MIF levels (2839 +/- 757.1 and 4404 +/- 1548.1, respectively) compared with noncystitis patients (681 +/- 75.2). CONCLUSION Urine MIF is elevated in IC/BPS patients with Hunner lesions and also in patients with other bladder inflammatory and painful conditions. MIF may also serve as a noninvasive biomarker to select IC/BPS patients more accurately for endoscopic evaluation and possible anti-inflammatory treatment. (c) 2018 Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- syndrome/interstitial cystitis
- prevalence
- expression
- diagnosis
- ulcers
- mif
- Urology & Nephrology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Urology
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- By the author/editor
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Vera, P. L.
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Preston, D. M.
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Moldwin, R. M.
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Erickson, D. R.
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Mowlazadeh, B.
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Ma, F.
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show more...
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Kouzoukas, D. E.
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Meyer-Siegler, K ...
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Fall, Magnus, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Urology
- By the university
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University of Gothenburg