High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment

• Background: Diarrheal illnesses in young children cause morbidity and preventable deaths in developing countries. We evaluated two high doses of Salovum (R) [Antisecretory Factor] to treat diarrhea in young children and followed up for recurrence 6 weeks post treatment. Methods: Forty children, 6-24 months old, admitted with acute diarrhea, to the Outpatient Department of Children's Hospital in Lahore, Pakistan were selected. The patients were randomly allocated to either Group A given 2 sachets, or to Group B, given 4 sachets. Each sachet contained 4 gram of Salovum (R) and was mixed with Oral Rehydration Salt solution. This mixture was administered perorally within the first 30 min of treatment. The trained nursing staff observed them for number of stools and consistency over every half hour for a total of 4 hours. Follow up for 6 weeks was done daily by telephone, or visits by the mothers. The results demonstrate that Salovum (R) provides a protective effect irrespective of the diarrhea causes. Results: Group B, given 4 sachets of Salovum (R) showed improved fecal consistency in 80% of the children compared to 50% in Group A within 30 minutes of treatment, p= 0.004. The number of diarrheal stools decreased over this time from seven to one/two over 4 hours in the two groups [p = 0.234]. None of the children showed a recurrence of diarrhea over the follow up period. Conclusion: Peroral high doses of Salovum (R) rapidly and safely counteract diarrhea in children followed by a diarrhea-free period of 6 weeks. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Paediatric diarrheal disease

Antisecretory Factor

Developing country

Recovery time

Follow up

inflammatory-bowel-disease

childhood diarrhea

menieres-disease

trial

food

Infectious Diseases

Publication and Content Type

ref (subject category)

art (subject category)