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Plasma N-glycans in...
Plasma N-glycans in colorectal cancer risk
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-06-05
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/268629
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https://gup.ub.gu.se/publication/268629URI
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https://doi.org/10.1038/s41598-018-26805-7DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasma W-glycosylation between colorectal cancer (CRC) cases and controls in one of the largest cohorts of its kind. A set of 633 CRC patients and 478 age and gender matched controls was analysed. Additionally, patients were stratified into four CRC stages. Moreover, W-glycan analysis was carried out in plasma of 40 patients collected prior to the initial diagnosis of CRC. Statistically significant differences were observed in the plasma N-glycome at all stages of CRC, this included a highly significant decrease in relation to the core fucosylated bi-antennary glycans F(6)A2G2 and F(6)A2G2S(6)1 (P < 0.0009). Stage 1 showed a unique biomarker signature compared to stages 2, 3 and 4. There were indications that at risk groups could be identified from the glycome (retrospective AUC = 0.77 and prospective AUC = 0.65). N-glycome biomarkers related to the pathogenic progress of the disease would be a considerable asset in a clinical setting and it could enable novel therapeutics to be developed to target the disease in patients at risk of progression.
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Theodoratou, E.
(author)
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Walsh, I.
(author)
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Adamczyk, Barbara,1985Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xadaba
(author)
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Stockmann, H.
(author)
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Agakov, F.
(author)
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Timofeeva, M.
(author)
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Trbojevic-Akmacic, I.
(author)
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Vuckovic, F.
(author)
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Duffy, F.
(author)
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McManus, C. A.
(author)
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Farrington, S. M.
(author)
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Dunlop, M. G.
(author)
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Perola, M.
(author)
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Lauc, G.
(author)
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Campbell, H.
(author)
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Rudd, P. M.
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC82045-2322
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Doherty, M.
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Theodoratou, E.
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Walsh, I.
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Adamczyk, Barbar ...
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Stockmann, H.
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Agakov, F.
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Timofeeva, M.
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Trbojevic-Akmaci ...
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Vuckovic, F.
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Duffy, F.
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McManus, C. A.
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Farrington, S. M ...
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Dunlop, M. G.
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Perola, M.
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Lauc, G.
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Campbell, H.
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Rudd, P. M.
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- MEDICAL AND HEALTH SCIENCES
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University of Gothenburg