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Translational studi...
Translational studies provide insights for the etiology and treatment of cortical bone osteoporosis
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- Brommage, Robert (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Best Practice & Research Clinical Endocrinology & Metabolism. - : Elsevier BV. - 1521-690X. ; 32:3, s. 329-340
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Abstract
Subject headings
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- Increasing attention is being focused on the important contributions of cortical bone to bone strength, fractures and osteoporosis therapies. Recent progress in human genome wide association studies in combination with high-throughput mouse gene knockout phenotyping efforts of multiple genes and advanced conditional gene inactivation in mouse models have successfully identified genes with crucial roles in cortical bone homeostasis. Particular attention in this review is given to genes, such as WNT16, POSTN and SFRP4, that differentially affect cortical and trabecular bone architecture. We propose that animal models of cortical bone metabolism will substantially contribute to developing anabolic osteoporosis therapies that improve cortical bone mass and reduce non-vertebral fracture risk. 0 (C) 2018 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- cortical bone
- WNT16
- SFRP4
- periostin
- genetic
- HR-pQCT
- quantitative computed-tomography
- hormone-related peptide
- human
- femoral-neck
- mineral density
- trabecular bone
- hip fracture
- growth-plate
- postmenopausal women
- parathyroid-hormone
- cathepsin k
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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