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Expression of ribos...
Expression of ribosomal and actin network proteins and immunochemotherapy resistance in diffuse large B cell lymphoma patients
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- Bram Ednersson, Susanne (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrens Univ Hosp, Dept Pathol, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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- Stenson, Martin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Kungalvs Hosp, Sect Haematol, Dept Med, Kungalv, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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- Stern, Mimmi (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Med, Sect Haematol, Boras, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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- Enblad, Gunilla (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Fagman, Henrik, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrens Univ Hosp, Dept Pathol, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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- Nilsson-Ehle, Herman, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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- Hasselblom, Sverker (author)
- Dept Res Dev & Educ, Halmstad, Region Halland, Sweden
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- Andersson, Per-Ola, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Med, Sect Haematol, Boras, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden
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(creator_code:org_t)
- 2018-05-16
- 2018
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 181:6, s. 770-781
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Abstract
Subject headings
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- Diffuse large B cell lymphoma (DLBCL) patients with early relapse or refractory disease have a very poor outcome. Immunochemotherapy resistance will probably, also in the era of targeted drugs, remain the major cause of treatment failure. We used proteomic mass spectrometry to analyse the global protein expression of micro-dissected formalin-fixed paraffin-embedded tumour tissues from 97 DLBCL patients: 44 with primary refractory disease or relapse within 1year from diagnosis (REF/REL), and 53 who were progression-free more than 5years after diagnosis (CURED). We identified 2127 proteins: 442 were found in all patients and 102 were differentially expressed. Sixty-five proteins were overexpressed in REF/REL patients, of which 46 were ribosomal proteins (RPs) compared with 2 of the 37 overexpressed proteins in CURED patients (P=76x10(-10)). Twenty of 37 overexpressed proteins in CURED patients were associated with actin regulation, compared with 1 of 65 in REF/REL patients (P=14x10(-9)). Immunohistochemical staining showed higher expression of RPS5 and RPL17 in REF/REL patients while MARCKS-like protein, belonging to the actin network, was more highly expressed in CURED patients. Even though functional studies aimed at individual proteins and protein interactions to evaluate potential clinical effect are needed, our findings suggest new mechanisms behind immunochemotherapy resistance in DLBCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- DLBCL
- proteomics
- immunochemotherapy resistance
- ribosomal
- actin
- rna-polymerase-i
- cancer cells
- cytoskeletal alterations
- therapeutic
- strategy
- multiple-myeloma
- drug-resistance
- gastric-cancer
- rho
- gtpases
- doxorubicin
- proliferation
- Hematology
- DLBCL
Publication and Content Type
- ref (subject category)
- art (subject category)
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