Search: onr:"swepub:oai:gup.ub.gu.se/268852" >
Investigating polyg...
Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.
- Article/chapterEnglish2019
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/268852
-
https://gup.ub.gu.se/publication/268852URI
-
https://doi.org/10.1111/bdi.12659DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:140390285URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18years] vs adulthood [>18years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Papiol, Sergi
(author)
-
Forstner, Andreas J
(author)
-
Heilbronner, Urs
(author)
-
Degenhardt, Franziska
(author)
-
Strohmaier, Jana
(author)
-
Adli, Mazda
(author)
-
Adorjan, Kristina
(author)
-
Akula, Nirmala
(author)
-
Alda, Martin
(author)
-
Anderson-Schmidt, Heike
(author)
-
Andlauer, Till Fm
(author)
-
Anghelescu, Ion-George
(author)
-
Ardau, Raffaella
(author)
-
Arias, Bárbara
(author)
-
Arolt, Volker
(author)
-
Aubry, Jean-Michel
(author)
-
Backlund, LenaKarolinska Institutet
(author)
-
Bartholdi, Kim
(author)
-
Bauer, Michael
(author)
-
Baune, Bernhard T
(author)
-
Becker, Thomas
(author)
-
Bellivier, Frank
(author)
-
Benabarre, Antonio
(author)
-
Bengesser, Susanne
(author)
-
Bhattacharjee, Abesh Kumar
(author)
-
Biernacka, Joanna M
(author)
-
Birner, Armin
(author)
-
Brichant-Petitjean, Clara
(author)
-
Budde, Monika
(author)
-
Cervantes, Pablo
(author)
-
Chillotti, CaterinaKarolinska Institutet
(author)
-
Cichon, Sven
(author)
-
Clark, Scott R
(author)
-
Colom, Francesc
(author)
-
Comes, Ashley L
(author)
-
Cruceanu, Cristiana
(author)
-
Czerski, Piotr M
(author)
-
Dannlowski, Udo
(author)
-
Dayer, Alexandre
(author)
-
Del Zompo, Maria
(author)
-
DePaulo, Jay Raymond
(author)
-
Dietrich, Detlef E
(author)
-
Étain, Bruno
(author)
-
Ethofer, Thomas
(author)
-
Falkai, Peter
(author)
-
Fallgatter, Andreas
(author)
-
Figge, Christian
(author)
-
Flatau, Laura
(author)
-
Folkerts, Here
(author)
-
Frisen, LouiseKarolinska Institutet
(author)
-
Frye, Mark A
(author)
-
Fullerton, Janice M
(author)
-
Gade, Katrin
(author)
-
Gard, Sébastien
(author)
-
Garnham, Julie S
(author)
-
Goes, Fernando S
(author)
-
Grigoroiu-Serbanescu, Maria
(author)
-
Gryaznova, Anna
(author)
-
Hake, Maria
(author)
-
Hauser, Joanna
(author)
-
Herms, Stefan
(author)
-
Hoffmann, Per
(author)
-
Hou, Liping
(author)
-
Jäger, Markus
(author)
-
Jamain, Stephane
(author)
-
Jiménez, Esther
(author)
-
Juckel, Georg
(author)
-
Kahn, Jean-Pierre
(author)
-
Kassem, Layla
(author)
-
Kelsoe, John
(author)
-
Kittel-Schneider, Sarah
(author)
-
Kliwicki, Sebastian
(author)
-
Klohn-Sagatholislam, Farah
(author)
-
Koller, Manfred
(author)
-
König, Barbara
(author)
-
Konrad, Carsten
(author)
-
Lackner, Nina
(author)
-
Laje, Gonzalo
(author)
-
Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt
(author)
-
Lang, Fabian U
(author)
-
Lavebratt, Catharina
(author)
-
Leboyer, Marion
(author)
-
Leckband, Susan G
(author)
-
Maj, MarioKarolinska Institutet
(author)
-
Manchia, Mirko
(author)
-
Martinsson, LinaKarolinska Institutet
(author)
-
McCarthy, Michael J
(author)
-
McElroy, Susan L
(author)
-
McMahon, Francis J
(author)
-
Mitchell, Philip B
(author)
-
Mitjans, Marina
(author)
-
Mondimore, Francis M
(author)
-
Monteleone, Palmiero
(author)
-
Nieratschker, Vanessa
(author)
-
Nievergelt, Caroline M
(author)
-
Novák, Tomas
(author)
-
Ösby, Urban
(author)
-
Pfennig, Andrea
(author)
-
Potash, James B
(author)
-
Reich-Erkelenz, Daniela
(author)
-
Reif, Andreas
(author)
-
Reimer, Jens
(author)
-
Reininghaus, Eva
(author)
-
Reitt, Markus
(author)
-
Ripke, Stephan
(author)
-
Rouleau, Guy A
(author)
-
Rybakowski, Janusz K
(author)
-
Schalling, Martin
(author)
-
Scherk, Harald
(author)
-
Schmauß, Max
(author)
-
Schofield, Peter R
(author)
-
Schubert, K Oliver
(author)
-
Schulte, Eva C
(author)
-
Schulz, Sybille
(author)
-
Senner, Fanny
(author)
-
Severino, Giovanni
(author)
-
Shekhtman, Tatyana
(author)
-
Shilling, Paul D
(author)
-
Simhandl, Christian
(author)
-
Slaney, Claire M
(author)
-
Spitzer, Carsten
(author)
-
Squassina, Alessio
(author)
-
Stamm, Thomas
(author)
-
Stegmaier, Sophia
(author)
-
Stierl, Sebastian
(author)
-
Stopkova, Pavla
(author)
-
Thiel, Andreas
(author)
-
Tighe, Sarah K
(author)
-
Tortorella, Alfonso
(author)
-
Turecki, Gustavo
(author)
-
Vieta, Eduard
(author)
-
Veeh, Julia
(author)
-
von Hagen, Martin
(author)
-
Wigand, Moritz E
(author)
-
Wiltfang, Jens
(author)
-
Witt, Stephanie
(author)
-
Wright, Adam
(author)
-
Zandi, Peter P
(author)
-
Zimmermann, Jörg
(author)
-
Nöthen, Markus
(author)
-
Rietschel, Marcella
(author)
-
Schulze, Thomas G
(author)
-
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
Related titles
-
In:Bipolar disorders: Wiley21:1, s. 68-751399-56181398-5647
Internet link
Find in a library
To the university's database
- By the author/editor
-
Kalman, Janos L
-
Papiol, Sergi
-
Forstner, Andrea ...
-
Heilbronner, Urs
-
Degenhardt, Fran ...
-
Strohmaier, Jana
-
show more...
-
Adli, Mazda
-
Adorjan, Kristin ...
-
Akula, Nirmala
-
Alda, Martin
-
Anderson-Schmidt ...
-
Andlauer, Till F ...
-
Anghelescu, Ion- ...
-
Ardau, Raffaella
-
Arias, Bárbara
-
Arolt, Volker
-
Aubry, Jean-Mich ...
-
Backlund, Lena
-
Bartholdi, Kim
-
Bauer, Michael
-
Baune, Bernhard ...
-
Becker, Thomas
-
Bellivier, Frank
-
Benabarre, Anton ...
-
Bengesser, Susan ...
-
Bhattacharjee, A ...
-
Biernacka, Joann ...
-
Birner, Armin
-
Brichant-Petitje ...
-
Budde, Monika
-
Cervantes, Pablo
-
Chillotti, Cater ...
-
Cichon, Sven
-
Clark, Scott R
-
Colom, Francesc
-
Comes, Ashley L
-
Cruceanu, Cristi ...
-
Czerski, Piotr M
-
Dannlowski, Udo
-
Dayer, Alexandre
-
Del Zompo, Maria
-
DePaulo, Jay Ray ...
-
Dietrich, Detlef ...
-
Étain, Bruno
-
Ethofer, Thomas
-
Falkai, Peter
-
Fallgatter, Andr ...
-
Figge, Christian
-
Flatau, Laura
-
Folkerts, Here
-
Frisen, Louise
-
Frye, Mark A
-
Fullerton, Janic ...
-
Gade, Katrin
-
Gard, Sébastien
-
Garnham, Julie S
-
Goes, Fernando S
-
Grigoroiu-Serban ...
-
Gryaznova, Anna
-
Hake, Maria
-
Hauser, Joanna
-
Herms, Stefan
-
Hoffmann, Per
-
Hou, Liping
-
Jäger, Markus
-
Jamain, Stephane
-
Jiménez, Esther
-
Juckel, Georg
-
Kahn, Jean-Pierr ...
-
Kassem, Layla
-
Kelsoe, John
-
Kittel-Schneider ...
-
Kliwicki, Sebast ...
-
Klohn-Sagatholis ...
-
Koller, Manfred
-
König, Barbara
-
Konrad, Carsten
-
Lackner, Nina
-
Laje, Gonzalo
-
Landén, Mikael, ...
-
Lang, Fabian U
-
Lavebratt, Catha ...
-
Leboyer, Marion
-
Leckband, Susan ...
-
Maj, Mario
-
Manchia, Mirko
-
Martinsson, Lina
-
McCarthy, Michae ...
-
McElroy, Susan L
-
McMahon, Francis ...
-
Mitchell, Philip ...
-
Mitjans, Marina
-
Mondimore, Franc ...
-
Monteleone, Palm ...
-
Nieratschker, Va ...
-
Nievergelt, Caro ...
-
Novák, Tomas
-
Ösby, Urban
-
Pfennig, Andrea
-
Potash, James B
-
Reich-Erkelenz, ...
-
Reif, Andreas
-
Reimer, Jens
-
Reininghaus, Eva
-
Reitt, Markus
-
Ripke, Stephan
-
Rouleau, Guy A
-
Rybakowski, Janu ...
-
Schalling, Marti ...
-
Scherk, Harald
-
Schmauß, Max
-
Schofield, Peter ...
-
Schubert, K Oliv ...
-
Schulte, Eva C
-
Schulz, Sybille
-
Senner, Fanny
-
Severino, Giovan ...
-
Shekhtman, Tatya ...
-
Shilling, Paul D
-
Simhandl, Christ ...
-
Slaney, Claire M
-
Spitzer, Carsten
-
Squassina, Aless ...
-
Stamm, Thomas
-
Stegmaier, Sophi ...
-
Stierl, Sebastia ...
-
Stopkova, Pavla
-
Thiel, Andreas
-
Tighe, Sarah K
-
Tortorella, Alfo ...
-
Turecki, Gustavo
-
Vieta, Eduard
-
Veeh, Julia
-
von Hagen, Marti ...
-
Wigand, Moritz E
-
Wiltfang, Jens
-
Witt, Stephanie
-
Wright, Adam
-
Zandi, Peter P
-
Zimmermann, Jörg
-
Nöthen, Markus
-
Rietschel, Marce ...
-
Schulze, Thomas ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Bipolar disorder ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet