Search: onr:"swepub:oai:gup.ub.gu.se/268983" > A molecular mechani...
Fältnamn | Indikatorer | Metadata |
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000 | 05189naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/268983 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-149315 | |
024 | 7 | a https://gup.ub.gu.se/publication/2689832 URI |
024 | 7 | a https://doi.org/10.1126/science.aao11572 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1493152 URI |
040 | a (SwePub)gud (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Barbier, Estelleu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)estba07 |
245 | 1 0 | a A molecular mechanism for choosing alcohol over an alternative reward |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2018 |
500 | a Funding agencies Swedish Research Council [2013-7434]; Stiftelsen Psykiatriska Forskningsfonden | |
520 | a Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which similar to 15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the g-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a gene-expression | |
653 | a animal-models | |
653 | a drug-use | |
653 | a addiction | |
653 | a behavior | |
653 | a cocaine | |
653 | a anxiety | |
653 | a brain | |
653 | a rats | |
653 | a transporters | |
653 | a Science & Technology - Other Topics | |
700 | 1 | a Dulman, R. S.u Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA4 aut |
700 | 1 | a Licheri, Valentinau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Göteborg, 413 90 Göteborg, Sweden4 aut0 (Swepub:gu)xlicva |
700 | 1 | a Augier, Gaëlleu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)gaeau73 |
700 | 1 | a Domi, Esiu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)esido51 |
700 | 1 | a Barchiesi, Riccardou Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)ricba75 |
700 | 1 | a Farris, S.u The Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712, USA4 aut |
700 | 1 | a Nätt, Danielu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)danis31 |
700 | 1 | a Mayfield, R. D.u The Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712, USA4 aut |
700 | 1 | a Adermark, Louise,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Göteborg, 413 90 Göteborg, Sweden4 aut0 (Swepub:gu)xadelo |
700 | 1 | a Heilig, Markusu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken4 aut0 (Swepub:liu)marhe41 |
700 | 1 | a Augier, Ericu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)eriau90 |
710 | 2 | a Linköpings universitetb Centrum för social och affektiv neurovetenskap4 org |
773 | 0 | t Scienced : American Association for the Advancement of Science (AAAS)g 360:6395q 360:6395x 0036-8075x 1095-9203 |
856 | 4 8 | u https://gup.ub.gu.se/publication/268983 |
856 | 4 8 | u https://doi.org/10.1126/science.aao1157 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149315 |
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