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  • Andersson, MariaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Univ Gothenburg, Dept Infect Dis, Guldhedsgatan 10B, S-41346 Gothenburg, Sweden (author)

Coinfection with Enteric Pathogens in East African Children with Acute Gastroenteritis-Associations and Interpretations

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • American Society of Tropical Medicine and Hygiene,2018

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/269089
  • https://gup.ub.gu.se/publication/269089URI
  • https://doi.org/10.4269/ajtmh.17-0473DOI
  • https://research.chalmers.se/publication/504163URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361008URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138600616URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Enteric coinfections among children in low-income countries are very common, but it is not well known if specific pathogen combinations are associated or have clinical importance. In this analysis, feces samples from children in Rwanda and Zanzibar less than 5 years of age, with (N = 994) or without (N = 324) acute diarrhea, were analyzed by realtime polymerase chain reaction targeting a wide range of pathogens. Associations were investigated by comparing codetection and mono-detection frequencies for all pairwise pathogen combinations. More than one pathogen was detected in 840 samples (65%). A negative association (coinfections being less common than expected from probability) was observed for rotavirus in combination with Shigella, Campylobacter, or norovirus genogroup II, but only in patients, which is statistically expected for agents that independently cause diarrhea. A positive correlation was observed, in both patients and controls, between Ct (threshold cycle) values for certain virulence factor genes in enteropathogenic Escherichia coli (EPEC) (eae and bfpA) and toxin genes in enterotoxigenic E. coli (eltB and estA), allowing estimation of how often these genes were present in the same bacteria. A significant positive association in patients only was observed for Shigella andEPEC-eae, suggesting that this coinfection might interact in a manner that enhances symptoms. Although interaction between pathogens that affect symptoms is rare, this work emphasizes the importance and difference in interpretation of coinfections depending on whether they are positively or negatively associated.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kabayiza, J. C.University of Rwanda,Univ Rwanda, Dept Pediat, Kigali, Rwanda (author)
  • Elfving, KristinaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Univ Gothenburg, Dept Infect Dis, Guldhedsgatan 10B, S-41346 Gothenburg, Sweden(Swepub:gu)xelfkr (author)
  • Nilsson, Staffan,1956Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Gothenburg, Sweden(Swepub:cth)staffan (author)
  • Msellem, M. I.Ministry of Health and Social Welfare,Minist Hlth, Zanzibar Malaria Eliminat Programme ZAMEP, Zanzibar, Tanzania (author)
  • Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)andma331 (author)
  • Bjorkman, A.Karolinska Institutet (author)
  • Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Univ Gothenburg, Dept Infect Dis, Guldhedsgatan 10B, S-41346 Gothenburg, Sweden(Swepub:gu)xberto (author)
  • Lindh, Magnus,1960Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Univ Gothenburg, Dept Infect Dis, Guldhedsgatan 10B, S-41346 Gothenburg, Sweden(Swepub:gu)xlmagr (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

Related titles

  • In:American Journal of Tropical Medicine and Hygiene: American Society of Tropical Medicine and Hygiene98:6, s. 1566-15700002-96371476-1645

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