Search: onr:"swepub:oai:gup.ub.gu.se/269565" >
NKG2D gene variatio...
NKG2D gene variation and susceptibility to viral bronchiolitis in childhood.
-
Pasanen, Anu (author)
-
Karjalainen, Minna K (author)
-
Kummola, Laura (author)
-
show more...
-
Waage, Johannes (author)
-
Bønnelykke, Klaus (author)
-
Ruotsalainen, Marja (author)
-
Piippo-Savolainen, Eija (author)
-
- Goksör, Emma, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Nuolivirta, Kirsi (author)
-
Chawes, Bo (author)
-
Vissing, Nadja (author)
-
Bisgaard, Hans (author)
-
Jartti, Tuomas (author)
-
Junttila, Ilkka (author)
-
- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Hallman, Mikko (author)
-
Korppi, Matti (author)
-
Rämet, Mika (author)
-
show less...
-
(creator_code:org_t)
- 2018-06-09
- 2018
- English.
-
In: Pediatric research. - : Springer Science and Business Media LLC. - 1530-0447 .- 0031-3998. ; 84, s. 451-457
- Related links:
-
https://www.nature.c...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Genetic factors associated with bronchiolitis are inadequately characterized. We therefore inspected a selected subpopulation of our previous genome-wide association study (GWAS) of bronchiolitis for overlap with known quantitative trait loci (QTLs) to identify susceptibility loci that potentially affect mRNA and protein levels.GWAS included a Finnish-Swedish case-control population (n=187), matched for age and site. We integrated GWAS variants (p<10-4) with QTL data. We subsequently verified allele-specific expression of identified QTLs by flow cytometry. Association of the resulting candidate loci with bronchiolitis was tested in three additional cohorts from Finland and Denmark (n=1201).Bronchiolitis-susceptibility variant rs10772271 resided within QTLs previously associated with NKG2D (NK group 2, member D) mRNA and protein levels. Flow cytometric analysis confirmed the association with protein level in NK cells. The GWAS susceptibility allele (A) of rs10772271 (odds ratio [OR]=2.34) corresponded with decreased NKG2D expression. The allele was nominally associated with bronchiolitis in one Finnish replicate (OR=1.50), and the other showed directional consistency (OR=1.43). No association was detected in Danish population CONCLUSIONS: The bronchiolitis GWAS susceptibility allele was linked to decreased NKG2D expression in the QTL data and in our expression analysis. We propose that reduced NKG2D expression predisposes infants to severe bronchiolitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Pasanen, Anu
-
Karjalainen, Min ...
-
Kummola, Laura
-
Waage, Johannes
-
Bønnelykke, Klau ...
-
Ruotsalainen, Ma ...
-
show more...
-
Piippo-Savolaine ...
-
Goksör, Emma, 19 ...
-
Nuolivirta, Kirs ...
-
Chawes, Bo
-
Vissing, Nadja
-
Bisgaard, Hans
-
Jartti, Tuomas
-
Junttila, Ilkka
-
Wennergren, Göra ...
-
Hallman, Mikko
-
Korppi, Matti
-
Rämet, Mika
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
- Articles in the publication
-
Pediatric resear ...
- By the university
-
University of Gothenburg