Search: onr:"swepub:oai:gup.ub.gu.se/270565" >
Cytomegalovirus Ser...
Cytomegalovirus Serostatus Affects Autoreactive NK Cells and Outcomes of IL2-Based Immunotherapy in Acute Myeloid Leukemia
-
- Bernson, Elin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Hallner, Alexander, 1990 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Sander, Frida Ewald (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
show more...
-
- Nicklasson, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Nilsson, Malin S. (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Christenson, Karin (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Aydin, Ebru (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Liljeqvist, Jan-Åke, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
Foa, R. (author)
-
- Aurelius, Johan, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Sahlgrenska Cancer Center,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
- Martner, Anna, 1979 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Bergh Thorén, Fredrik, 1976 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
show less...
-
(creator_code:org_t)
- 2018-09-04
- 2018
- English.
-
In: Cancer Immunology Research. - : American Association for Cancer Research (AACR). - 2326-6066 .- 2326-6074. ; 6:9, s. 1110-1119
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Human cytomegalovirus (CMV) infection is reported to promote NK cell differentiation and education. The CMV-induced generation of highly differentiated adaptive-like NK cells has been proposed to affect favorably on the maintenance of remission in patients with acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT). The impact of CMV infection and adaptive-like NK cells on relapse and survival of patients with AML not receiving allo-SCT remains unknown. We assayed CMV IgG serostatus to determine past CMV infection in 81 nontransplanted AML patients who were receiving relapse-prevention immunotherapy comprising histamine dihydrochloride and low-dose interleukin-2 (HDC/IL2; NCT01347996). CMV seropositivity correlated negatively with leukemia-free and overall survival of patients receiving HDC/IL2, but did not correlate with outcomes in a contemporary control cohort. Analysis of outcome after stratification of patients based on concordant or discordant killer immunoglobulin-like receptor (KIR) and HLA genotypes implied that the negative impact of CMV seropositivity was restricted to patients lacking a ligand to inhibitory KIRs (iKIR). Previous CMV infection was also associated with fewer NK cells expressing only nonself iKIRs (NS-iKIR). We propose that CMV-driven NK cell education depletes the population of NS-iKIR NK cells, which in turn reduces the clinical benefit of relapse-preventive immunotherapy in AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- NATURAL-KILLER-CELLS; RELAPSE RISK EVIDENCE; CLASS-I MOLECULES; COMPLEX CLASS-I; MHC CLASS-I; INHIBITORY RECEPTORS; DOWN-REGULATION; HLA GENOTYPES; TRANSPLANTATION; INFECTION
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bernson, Elin, 1 ...
-
Hallner, Alexand ...
-
Sander, Frida Ew ...
-
Nicklasson, Mali ...
-
Nilsson, Malin S ...
-
Christenson, Kar ...
-
show more...
-
Aydin, Ebru
-
Liljeqvist, Jan- ...
-
Brune, Mats, 195 ...
-
Foa, R.
-
Aurelius, Johan, ...
-
Martner, Anna, 1 ...
-
Hellstrand, Kris ...
-
Bergh Thorén, Fr ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Cancer Immunolog ...
- By the university
-
University of Gothenburg