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New strategies for ...
New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-11-28
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Oxford University Press (OUP),2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/270762
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https://gup.ub.gu.se/publication/270762URI
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https://doi.org/10.1093/ehjcvp/pvx031DOI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most interventions without evidence of attenuation or increase in risk at low LDL-C levels. Opportunities for innovation in dyslipidaemia treatment should address the substantial risk of lipid-associated cardiovascular events among patients optimally treated per guidelines but who cannot achieve LDL-C goals and who could benefit from additional LDL-C-lowering therapy or experience side effects of statins. Fresh approaches are needed to identify promising drug targets early and develop them efficiently. The Cardiovascular Round Table of the European Society of Cardiology (ESC) convened a workshop to discuss new lipid-lowering strategies for cardiovascular risk reduction. Opportunities to improve treatment approaches and the efficient study of new therapies were explored. Circulating biomarkers may not be fully reliable proxy indicators of the relationship between treatment effect and clinical outcome. Mendelian randomization studies may better inform development strategies and refine treatment targets before Phase 3. Trials should match the drug to appropriate lipid and patient profile, and guidelines may move towards a precision-based approach to individual patient management. Stakeholder collaboration is needed to ensure continued innovation and better international coordination of both regulatory aspects and guidelines. It should be noted that risk may also be addressed through increased attention to other risk factors such as smoking, hypertension, overweight, and inactivity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Shear, Chuck
(author)
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De Graeff, Pieter
(author)
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Boulton, Caroline
(author)
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Catapano, Alberico L
(author)
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Stough, Wendy Gattis
(author)
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Carlsson, Stefan C
(author)
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De Backer, Guy
(author)
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Emmerich, Joseph
(author)
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Greenfeder, Scott
(author)
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Kim, Albert M
(author)
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Lautsch, Dominik
(author)
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Nguyen, Tu
(author)
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Nissen, Steven E
(author)
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Prasad, Krishna
(author)
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Ray, Kausik K
(author)
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Robinson, Jennifer G
(author)
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Sasiela, William J
(author)
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Bruins Slot, Karsten
(author)
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Stroes, Erik
(author)
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Thuren, Tom
(author)
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Van der Schueren, Bart
(author)
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Velkovski-Rouyer, Maja
(author)
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Wasserman, Scott M
(author)
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Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwikol
(author)
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Zouridakis, Emmanouil
(author)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
Related titles
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In:European heart journal. Cardiovascular pharmacotherapy: Oxford University Press (OUP)4:2, s. 119-1272055-68452055-6837
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Graham, Ian
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Shear, Chuck
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De Graeff, Piete ...
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Boulton, Carolin ...
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Catapano, Alberi ...
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Stough, Wendy Ga ...
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Carlsson, Stefan ...
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De Backer, Guy
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Emmerich, Joseph
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Greenfeder, Scot ...
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Kim, Albert M
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Lautsch, Dominik
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Nguyen, Tu
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Nissen, Steven E
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Prasad, Krishna
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Ray, Kausik K
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Robinson, Jennif ...
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Sasiela, William ...
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Bruins Slot, Kar ...
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Stroes, Erik
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Thuren, Tom
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Van der Schueren ...
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Velkovski-Rouyer ...
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Wasserman, Scott ...
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Wiklund, Olov, 1 ...
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Zouridakis, Emma ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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European heart j ...
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University of Gothenburg