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Uncovering the comp...
Uncovering the complex genetics of human temperament
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Zwir, Igor (author)
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Arnedo, Javier (author)
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Del-Val, Coral (author)
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Pulkki-Råback, Laura (author)
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Konte, Betina (author)
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Yang, Sarah S. (author)
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Romero-Zaliz, Rocio (author)
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Hintsanen, Mirka (author)
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Cloninger, Kevin M. (author)
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- Garcia, Danilo, 1973 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Svrakic, Dragan M. (author)
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Rozsa, Sandor (author)
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Martinez, Maribel (author)
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Lyytikäinen, Leo-Pekka (author)
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Giegling, Ina (author)
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Kähönen, Mika (author)
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Hernandez-Cuervo, Helena (author)
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Seppälä, Ilkka (author)
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Raitoharju, Emma (author)
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de Erausquin, Gabriel A. (author)
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Raitakari, Olli (author)
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Rujescu, Dan (author)
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Postolache, Teodor T. (author)
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Sung, Joohon (author)
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Keltikangas-Järvinen, Liisa (author)
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Lehtimäki, Terho (author)
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Cloninger, C. Robert (author)
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(creator_code:org_t)
- 2018-10-02
- 2020
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 25:10, s. 2275-2294
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Experimental studies of learning suggest that human temperament may depend on the molecular mechanisms for associative conditioning, which are highly conserved in animals. The main genetic pathways for associative conditioning are known in experimental animals, but have not been identified in prior genome-wide association studies (GWAS) of human temperament. We used a data-driven machine learning method for GWAS to uncover the complex genotypic–phenotypic networks and environmental interactions related to human temperament. In a discovery sample of 2149 healthy Finns, we identified sets of single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (i.e., SNP sets) regardless of phenotype. Second, we identified 3 clusters of people with distinct temperament profiles measured by the Temperament and Character Inventory regardless of genotype. Third, we found 51 SNP sets that identified 736 gene loci and were significantly associated with temperament. The identified genes were enriched in pathways activated by associative conditioning in animals, including the ERK, PI3K, and PKC pathways. 74% of the identified genes were unique to a specific temperament profile. Environmental influences measured in childhood and adulthood had small but significant effects. We confirmed the replicability of the 51 Finnish SNP sets in healthy Korean (90%) and German samples (89%), as well as their associations with temperament. The identified SNPs explained nearly all the heritability expected in each sample (37–53%) despite variable cultures and environments. We conclude that human temperament is strongly influenced by more than 700 genes that modulate associative conditioning by molecular processes for synaptic plasticity and long-term memory.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- Personality
- Genetics
- Temperament
- Machine Learning.
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zwir, Igor
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Arnedo, Javier
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Del-Val, Coral
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Pulkki-Råback, L ...
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Konte, Betina
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Yang, Sarah S.
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show more...
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Romero-Zaliz, Ro ...
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Hintsanen, Mirka
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Cloninger, Kevin ...
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Garcia, Danilo, ...
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Svrakic, Dragan ...
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Rozsa, Sandor
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Martinez, Maribe ...
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Lyytikäinen, Leo ...
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Giegling, Ina
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Kähönen, Mika
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Hernandez-Cuervo ...
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Seppälä, Ilkka
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Raitoharju, Emma
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de Erausquin, Ga ...
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Raitakari, Olli
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Rujescu, Dan
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Postolache, Teod ...
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Sung, Joohon
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Keltikangas-Järv ...
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Lehtimäki, Terho
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Cloninger, C. Ro ...
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg