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The extracellular m...
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Delbro, Dick,1950-Örebro universitet,Institutionen för medicinska vetenskaper
(author)
The extracellular matrix-degrading protein ADAMTS5 is expressed in the nuclei of urothelial cells in healthy rats
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-01-15
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Medical Journals Sweden AB,2018
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LIBRIS-ID:oai:gup.ub.gu.se/272066
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https://gup.ub.gu.se/publication/272066URI
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https://doi.org/10.1080/21681805.2017.1422015DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64508URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies:Anna-Lisa and Bror Björnsson's Research Foundation Martha and Gustaf Ågren's Research Foundation Örebro University
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Objective: The aim of this study was to investigate whether protein expression of the extracellular matrix-degrading protease ADAMTS5 can be demonstrated in the urinary bladder of healthy rats, and, if so, to determine the localization of this enzyme. Materials and methods: The experiments were conducted with eight inbred male Sprague-Dawley rats. Immunohistochemistry was used to investigate the expression of ADAMTS5 in the urinary bladder. Negative controls were established by either excluding the primary antibody or applying the antibody after it had been preabsorbed with its immunogenic peptide. Confocal microscopy was used to visualize the distribution of ADAMTS5 in the urinary bladder tissue. Results: Immunoreactivity for ADAMTS5 was demonstrated in the urothelium and in the detrusor. This expression was localized not only in the cytoplasm, but also in the nuclei. Confocal microscopy corroborated these findings. Conclusion: Expression of ADAMTS5 was demonstrated in the cytoplasm as well as in the nuclei of the urothelium and detrusor cells, suggesting that it may play a role at the transcriptional level.
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Hallsberg, Lena,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xhalll
(author)
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Peeker, Ralph,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy. University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xpeera
(author)
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Scherbak, Nikolai,1967-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)nsk
(author)
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Fall, Magnus,1941Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xfalma
(author)
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Godtman, Rebecka Arnsrud,1981Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xgodre
(author)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Scandinavian Journal of Urology: Medical Journals Sweden AB52:2, s. 139-1422168-18052168-1813
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