The extracellular matrix-degrading protein ADAMTS5 is expressed in the nuclei of urothelial cells in healthy rats

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Delbro, Dick,1950-Örebro universitet,Institutionen för medicinska vetenskaper (author)

The extracellular matrix-degrading protein ADAMTS5 is expressed in the nuclei of urothelial cells in healthy rats

Article/chapterEnglish2018

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2018-01-15
Medical Journals Sweden AB,2018

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LIBRIS-ID:oai:gup.ub.gu.se/272066
https://gup.ub.gu.se/publication/272066URI
https://doi.org/10.1080/21681805.2017.1422015DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64508URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies:Anna-Lisa and Bror Björnsson's Research Foundation Martha and Gustaf Ågren's Research Foundation Örebro University
Objective: The aim of this study was to investigate whether protein expression of the extracellular matrix-degrading protease ADAMTS5 can be demonstrated in the urinary bladder of healthy rats, and, if so, to determine the localization of this enzyme. Materials and methods: The experiments were conducted with eight inbred male Sprague-Dawley rats. Immunohistochemistry was used to investigate the expression of ADAMTS5 in the urinary bladder. Negative controls were established by either excluding the primary antibody or applying the antibody after it had been preabsorbed with its immunogenic peptide. Confocal microscopy was used to visualize the distribution of ADAMTS5 in the urinary bladder tissue. Results: Immunoreactivity for ADAMTS5 was demonstrated in the urothelium and in the detrusor. This expression was localized not only in the cytoplasm, but also in the nuclei. Confocal microscopy corroborated these findings. Conclusion: Expression of ADAMTS5 was demonstrated in the cytoplasm as well as in the nuclei of the urothelium and detrusor cells, suggesting that it may play a role at the transcriptional level.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
ADAMTS5
aggrecanase
confocal laser scanning microscopy
immunohistochemistry
nuclear
rat urothelium
Urology & Nephrology
ADAMTS5

Added entries (persons, corporate bodies, meetings, titles ...)

Hallsberg, Lena,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xhalll (author)
Peeker, Ralph,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy. University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xpeera (author)
Scherbak, Nikolai,1967-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)nsk (author)
Fall, Magnus,1941Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xfalma (author)
Godtman, Rebecka Arnsrud,1981Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xgodre (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Scandinavian Journal of Urology: Medical Journals Sweden AB52:2, s. 139-1422168-18052168-1813

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