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BATLAS: Deconvoluting Brown Adipose Tissue
- Perdikari, A. (author)
- Leparc, G. G. (author)
- Balaz, M. (author)
- show more...
- Pires, N. D. (author)
- Sun, W. F. (author)
- Fernandez-Albert, F. (author)
- Muller, S. (author)
- Akchiche, N. (author)
- Dong, H. (author)
- Balazova, L. (author)
- Opitz, L. (author)
- Roder, E. (author)
- Klein, H. (author)
- Stefanicka, P. (author)
- Varga, L. (author)
- Nuutila, P. (author)
- Virtanen, K. A. (author)
- Niemi, T. (author)
- Taittonen, M. (author)
- Rudofsky, G. (author)
- Ukropec, J. (author)
- Stupka, E. (author)
- Neubauer, H. (author)
- Wolfrum, C. (author)
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- (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
- In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 25:3
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes. By combining mouse and human transcriptome data, we identify a gene signature that can classify brown and white adipocytes in mice and men. Using a machine-learning-based cell deconvolution approach, we develop an algorithm proficient in calculating the brown adipocyte content in complex human and mouse biopsies. Applying this algorithm, we can show in a human weight loss study that brown adipose tissue (BAT) content is associated with energy expenditure and the propensity to lose weight. This online available tool can be used for in-depth characterization of complex adipose tissue samples and may support the development of therapeutic strategies to increase energy expenditure in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- functional-characterization
- white adipocytes
- receptor agonist
- adult
- humans
- fat
- activation
- distinct
- brite
- cold
- cell
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Perdikari, A.
- Leparc, G. G.
- Balaz, M.
- Pires, N. D.
- Lidell, Martin, ...
- Sun, W. F.
- show more...
- Fernandez-Albert ...
- Muller, S.
- Akchiche, N.
- Dong, H.
- Balazova, L.
- Opitz, L.
- Roder, E.
- Klein, H.
- Stefanicka, P.
- Varga, L.
- Nuutila, P.
- Virtanen, K. A.
- Niemi, T.
- Taittonen, M.
- Rudofsky, G.
- Ukropec, J.
- Enerbäck, Sven, ...
- Stupka, E.
- Neubauer, H.
- Wolfrum, C.
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
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- Cell Reports
- By the university
- University of Gothenburg
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