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BATLAS: Deconvoluti...
BATLAS: Deconvoluting Brown Adipose Tissue
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Perdikari, A. (author)
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Leparc, G. G. (author)
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Balaz, M. (author)
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Pires, N. D. (author)
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- Lidell, Martin, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Sun, W. F. (author)
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Fernandez-Albert, F. (author)
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Muller, S. (author)
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Akchiche, N. (author)
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Dong, H. (author)
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Balazova, L. (author)
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Opitz, L. (author)
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Roder, E. (author)
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Klein, H. (author)
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Stefanicka, P. (author)
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Varga, L. (author)
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Nuutila, P. (author)
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Virtanen, K. A. (author)
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Niemi, T. (author)
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Taittonen, M. (author)
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Rudofsky, G. (author)
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Ukropec, J. (author)
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Stupka, E. (author)
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Neubauer, H. (author)
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Wolfrum, C. (author)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 25:3
- Related links:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes. By combining mouse and human transcriptome data, we identify a gene signature that can classify brown and white adipocytes in mice and men. Using a machine-learning-based cell deconvolution approach, we develop an algorithm proficient in calculating the brown adipocyte content in complex human and mouse biopsies. Applying this algorithm, we can show in a human weight loss study that brown adipose tissue (BAT) content is associated with energy expenditure and the propensity to lose weight. This online available tool can be used for in-depth characterization of complex adipose tissue samples and may support the development of therapeutic strategies to increase energy expenditure in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- functional-characterization
- white adipocytes
- receptor agonist
- adult
- humans
- fat
- activation
- distinct
- brite
- cold
- cell
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Perdikari, A.
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Leparc, G. G.
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Balaz, M.
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Pires, N. D.
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Lidell, Martin, ...
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Sun, W. F.
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show more...
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Fernandez-Albert ...
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Muller, S.
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Akchiche, N.
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Dong, H.
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Balazova, L.
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Opitz, L.
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Roder, E.
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Klein, H.
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Stefanicka, P.
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Varga, L.
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Nuutila, P.
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Virtanen, K. A.
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Niemi, T.
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Taittonen, M.
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Rudofsky, G.
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Ukropec, J.
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Enerbäck, Sven, ...
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Stupka, E.
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Neubauer, H.
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Wolfrum, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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University of Gothenburg