Determination of T Follicular Helper Cell Fate by Dendritic Cells

• T follicular helper (Tfh) cells are a specialized subset of CD4(+) T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4(+) effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability of multiple DC subsets and related lineages to support the Tfh differentiation program.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

dendritic cell

Tfh cell

DC subset

DC migration

humoral response

vaccine

humoral immune-responses

antigen-presenting cells

draining

lymph-nodes

in-vivo

b-cell

langerhans cells

cutting edge

cd28-deficient mice

chemokine receptor

antibody-responses

Immunology

Publication and Content Type

ref (subject category)

art (subject category)