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Inflammation marker...
Inflammation marker and risk of pancreatic cancer: A nested case-control study within the EPIC cohort
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Grote, V. A. (author)
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Kaaks, R. (author)
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Nieters, A. (author)
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Tjønneland, A. (author)
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Halkjær, J. (author)
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Overvad, K. (author)
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Skjelbo Nielsen, M. R. (author)
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Boutron-Ruault, M. C. (author)
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Clavel-Chapelon, F. (author)
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Racine, A. (author)
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Teucher, B. (author)
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Becker, S. (author)
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Pischon, T. (author)
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Boeing, H. (author)
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Trichopoulou, A. (author)
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Cassapa, C. (author)
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Stratigakou, V. (author)
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Palli, D. (author)
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Krogh, V. (author)
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Tumino, R. (author)
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Vineis, P. (author)
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Panico, S. (author)
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Rodríguez, L. (author)
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Duell, E. J. (author)
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Sánchez, M. J. (author)
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Dorronsoro, M. (author)
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Navarro, C. (author)
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Gurrea, A. B. (author)
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Siersema, P. D. (author)
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Peeters, P. H.M. (author)
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- Ye, W. (author)
- Karolinska Institutet
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Näringsforskning
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Khaw, K. T. (author)
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Wareham, N. (author)
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Allen, N. E. (author)
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Travis, R. C. (author)
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Fedirko, V. (author)
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Jenab, M. (author)
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Michaud, D. S. (author)
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Chuang, S. C. (author)
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Romaguera, D. (author)
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Bueno-De-Mesquita, H. B. (author)
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Rohrmann, S. (author)
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(creator_code:org_t)
- 2012-04-26
- 2012
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 106, s. 1866-1874
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Background: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. Results: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. Conclusion: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer. © 2012 Cancer Research UK.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- CRP
- EPIC
- IL-6
- inflammation
- pancreatic cancer
- TNF receptor
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Grote, V. A.
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Kaaks, R.
-
Nieters, A.
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Tjønneland, A.
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Halkjær, J.
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Overvad, K.
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show more...
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Skjelbo Nielsen, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Racine, A.
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Teucher, B.
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Becker, S.
-
Pischon, T.
-
Boeing, H.
-
Trichopoulou, A.
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Cassapa, C.
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Stratigakou, V.
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Palli, D.
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Krogh, V.
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Tumino, R.
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Vineis, P.
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Panico, S.
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Rodríguez, L.
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Duell, E. J.
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Sánchez, M. J.
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Dorronsoro, M.
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Navarro, C.
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Gurrea, A. B.
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Siersema, P. D.
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Peeters, P. H.M.
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Ye, W.
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Sund, Malin, 197 ...
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Lindkvist, Björn
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Johansen, Dorthe
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Khaw, K. T.
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Wareham, N.
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Allen, N. E.
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Travis, R. C.
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Fedirko, V.
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Jenab, M.
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Michaud, D. S.
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Chuang, S. C.
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Romaguera, D.
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Bueno-De-Mesquit ...
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Rohrmann, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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British Journal ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Umeå University