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Inflammation marker...
Inflammation marker and risk of pancreatic cancer: A nested case-control study within the EPIC cohort
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-04-26
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Springer Science and Business Media LLC,2012
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/273382
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https://gup.ub.gu.se/publication/273382URI
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https://doi.org/10.1038/bjc.2012.172DOI
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https://lup.lub.lu.se/record/2802885URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124637697URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56418URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. Results: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. Conclusion: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer. © 2012 Cancer Research UK.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kaaks, R.
(author)
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Nieters, A.
(author)
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Tjønneland, A.
(author)
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Halkjær, J.
(author)
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Overvad, K.
(author)
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Skjelbo Nielsen, M. R.
(author)
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Boutron-Ruault, M. C.
(author)
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Clavel-Chapelon, F.
(author)
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Racine, A.
(author)
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Teucher, B.
(author)
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Becker, S.
(author)
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Pischon, T.
(author)
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Boeing, H.
(author)
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Trichopoulou, A.
(author)
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Cassapa, C.
(author)
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Stratigakou, V.
(author)
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Palli, D.
(author)
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Krogh, V.
(author)
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Tumino, R.
(author)
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Vineis, P.
(author)
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Panico, S.
(author)
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Rodríguez, L.
(author)
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Duell, E. J.
(author)
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Sánchez, M. J.
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Dorronsoro, M.
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Navarro, C.
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Gurrea, A. B.
(author)
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Siersema, P. D.
(author)
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Peeters, P. H.M.
(author)
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Ye, W.Karolinska Institutet
(author)
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Sund, Malin,1972-Umeå universitet,Kirurgi,Näringsforskning(Swepub:umu)masu0021
(author)
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Lindkvist, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlibjo
(author)
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Johansen, DortheLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)kirm-djo
(author)
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Khaw, K. T.
(author)
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Wareham, N.
(author)
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Allen, N. E.
(author)
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Travis, R. C.
(author)
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Fedirko, V.
(author)
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Jenab, M.
(author)
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Michaud, D. S.
(author)
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Chuang, S. C.
(author)
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Romaguera, D.
(author)
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Bueno-De-Mesquita, H. B.
(author)
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Rohrmann, S.
(author)
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Karolinska InstitutetKirurgi
(creator_code:org_t)
Related titles
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In:British Journal of Cancer: Springer Science and Business Media LLC106, s. 1866-18740007-09201532-1827
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- By the author/editor
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Grote, V. A.
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Kaaks, R.
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Nieters, A.
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Tjønneland, A.
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Halkjær, J.
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Overvad, K.
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show more...
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Skjelbo Nielsen, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Racine, A.
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Teucher, B.
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Becker, S.
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Pischon, T.
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Boeing, H.
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Trichopoulou, A.
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Cassapa, C.
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Stratigakou, V.
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Palli, D.
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Krogh, V.
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Tumino, R.
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Vineis, P.
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Panico, S.
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Rodríguez, L.
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Duell, E. J.
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Sánchez, M. J.
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Dorronsoro, M.
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Navarro, C.
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Gurrea, A. B.
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Siersema, P. D.
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Peeters, P. H.M.
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Ye, W.
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Sund, Malin, 197 ...
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Lindkvist, Björn
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Johansen, Dorthe
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Khaw, K. T.
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Wareham, N.
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Allen, N. E.
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Travis, R. C.
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Fedirko, V.
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Jenab, M.
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Michaud, D. S.
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Chuang, S. C.
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Romaguera, D.
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Bueno-De-Mesquit ...
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Rohrmann, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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British Journal ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Umeå University