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Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures
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Pujia, A. (author)
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Russo, C. (author)
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Maurotti, S. (author)
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Pujia, R. (author)
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Mollace, V. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Montalcini, T. (author)
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(creator_code:org_t)
- 2018-09-14
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 10:9
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Abstract
Subject headings
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- Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Citrus bergamia Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate -catenin expression (p = 0.001), osteoblast differentiation markers (e.g., RUNX2 and COL1A), and downregulate RANKL (p = 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through the -catenin pathway. In vivo studies are necessary to fully understand Bergamot's role against bone resorption.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- polyphenols
- citrus fruits
- Bergamot
- osteoporosis
- Saos-2
- bone cells
- -catenin
- randomized controlled-trial
- estrogen plus progestin
- mesenchymal
- stem-cell
- postmenopausal women
- osteoblast differentiation
- mineral
- density
- protein-kinase
- hip fracture
- osteoporosis
- expression
- Nutrition & Dietetics
- quillan dj
- 1995
- bone
- v16
- p415
Publication and Content Type
- ref (subject category)
- art (subject category)
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