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Possible mechanisms...
Possible mechanisms behind cardiac troponin elevations
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- Hammarsten, Ola (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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Mair, J. (author)
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Mockel, M. (author)
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Lindahl, B. (author)
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Jaffe, A. S. (author)
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(creator_code:org_t)
- 2018-08-23
- 2018
- English.
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In: Biomarkers. - : Informa UK Limited. - 1354-750X .- 1366-5804. ; 23:8, s. 725-734
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Abstract
Subject headings
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- Cardiac-specific troponins are elevated in blood following cardiac injury and are the preferred diagnostic biomarkers when acute myocardial infarction is suspected clinically. Cardiac troponin (cTn) elevations are also observed in clinical conditions without obvious connection to cardiac injury. Irrespective of the underlying condition, cTn elevation is linked to a poor prognosis, even if the elevation is stable over time. Here, we explore mechanisms that may lead to cTn elevations, including necrosis, apoptosis, necroptosis, cell wounds and decreased clearance. The aim is to broaden the perspective of how we interpret unexpected cTn elevations in patients. The cTn elevations may not be able to serve as direct proof of myocardial necrosis especially in the absence of a clear-cut reason for its release.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiac troponin I
- cardiac troponin T
- myocardial injury
- release
- reversible
- necrosis
- apoptosis
- acute myocardial-infarction
- acute coronary syndrome
- creatine-kinase
- skeletal-muscle
- cardiomyocyte apoptosis
- myotonic-dystrophy
- enzyme
- levels
- cell-death
- t levels
- heart
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Publication and Content Type
- ref (subject category)
- art (subject category)
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