Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease

INTRODUCTION: The Alzheimer's Association convened a multidisciplinary workgroup to develop appropriate use criteria to guide the safe and optimal use of the lumbar puncture procedure and cerebrospinal fluid (CSF) testing for Alzheimer's disease pathology detection in the diagnostic process. METHODS: The workgroup, experienced in the ethical use of lumbar puncture and CSF analysis, developed key research questions to guide the systematic review of the evidence and developed clinical indications commonly encountered in clinical practice based on key patient groups in whom the use of lumbar puncture and CSF may be considered as part of the diagnostic process. Based on their expertise and interpretation of the evidence from systematic review, members rated each indication as appropriate or inappropriate. RESULTS: The workgroup finalized 14 indications, rating 6 appropriate and 8 inappropriate. DISCUSSION: In anticipation of the emergence of more reliable CSF analysis platforms, the manuscript offers important guidance to health-care practitioners and suggestions for implementation and future research. Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Alzheimer's disease pathology
Amyloid PET
AUC
CSF Aβ-42
diagnostic utilities
MCI
Modified Delphi
p-tau181
PICOTS (population
interventions
comparisons
outcomes
timing
and settings) framework
SCD
t-tau
LP

Arias, J. (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Galasko, D. (author)
Molinuevo, J. L. (author)
Salloway, S. (author)
Schindler, S. (author)
Carrillo, M. C. (author)
Hendrix, J. A. (author)
Ross, A. (author)
Illes, J. (author)
Ramus, C. (author)
Fifer, S. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley14:11, s. 1505-15211552-5279
In:Alzheimer's & Dementia: Wiley14:11, s. 1505-15211552-5260

By the author/editor: Shaw, L. M.; Arias, J.; Blennow, Kaj, 19 ...; Galasko, D.; Molinuevo, J. L.; Salloway, S.; show more...; Schindler, S.; Carrillo, M. C.; Hendrix, J. A.; Ross, A.; Illes, J.; Ramus, C.; Fifer, S.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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