Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure: A multi-centre efficacy study using the Reitan Catheter Pump (RCP)

Keeble, T. R.Anglia Ruskin University,Basildon and Thurrock University Hospitals (author)

Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m(2) in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (+/- 6.3) hours. The RCP increased CI from 1.84 L/min/m(2) (+/- 0.27), to 2.41 L/min/m(2) (+/- 0.45, p = 0.04), increased urine output (71 mL/h (+/- 65) to 227 ml/h (+/- 179) (p = 0.006) with a concomitant reduction in serum creatinine (188 mu mol/L (+/- 87) to 161 mu mol/L (+/- 78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thromboembolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications. (c) 2018 Published by Elsevier B.V.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Decompensated heart failure
Congestion
Cardiac support
Renal dysfunction
ventricular assist devices
circulatory support
relax-ahf
dysfunction
serelaxin
outcomes

Karamasis, G. V.Basildon and Thurrock University Hospitals,Anglia Ruskin University (author)
Rothman, M. T.National Health Service Trust, NHS England (author)
Ricksten, Sven-Erik,1953University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care(Swepub:gu)xricsv (author)
Ferrari, M.Friedrich Schiller University Jena,Helios Clinic Wiesbaden (HSK) (author)
Hullin, R.Lausanne University Hospital (author)
Scherstén, FredrikLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-fds (author)
Reitan, OyvindLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,CardioBridge GmbH(Swepub:lu)kard-ore (author)
Kirking, S. T.CardioBridge GmbH (author)
Cleland, J. G. F.Royal Brompton Hospital,University of Glasgow (author)
Smith, E. J.National Health Service Trust, NHS England (author)
Anglia Ruskin UniversityBasildon and Thurrock University Hospitals (creator_code:org_t)

By the author/editor: Keeble, T. R.; Karamasis, G. V.; Rothman, M. T.; Ricksten, Sven-E ...; Ferrari, M.; Hullin, R.; show more...; Scherstén, Fredr ...; Reitan, Oyvind; Kirking, S. T.; Cleland, J. G. F ...; Smith, E. J.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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