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Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
- Syed, Ismail (author)
- Lee, Jennifer (author)
- Peroni, Odile D (author)
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- Yore, Mark M (author)
- Moraes-Vieira, Pedro M (author)
- Santoro, Anna (author)
- Wellenstein, Kerry (author)
- McGraw, Timothy E (author)
- Saghatelian, Alan (author)
- Kahn, Barbara B (author)
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- (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
- In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 28:4, s. 543-546
- Journal article (peer-reviewed)
Abstract
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- PAHSAs are anti-diabetic and anti-inflammatory lipids. Syed et al. identify numerous experimental differences that likely account for the failure of Pflimlin et al. to observe PAHSA beneficial effects. The differences include different HFDs resulting in minimal/no glucose intolerance, different assay conditions, an LC-MS protocol that was not validated, and use of olive oil, a bioactive nutrient that improves glucose tolerance, as a vehicle.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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- University of Gothenburg
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