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  • Godang, Kristin (author)

The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/274982
  • https://gup.ub.gu.se/publication/274982URI
  • https://doi.org/10.1530/EC-18-0259DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140081519URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors.To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism.119 patients previously randomized to observation (OBS; n=58) or parathyroidectomy (PTX; n=61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included. Main outcome measures for this study were the differences in fat mass, markers for lipid and glucose metabolism between OBS and PTX 5 years after randomization.In the OBS group, total cholesterol (Total-C) decreased from mean 5.9 (±1.1) to 5.6 (±1.0)mmol/L (P=0.037) and LDL cholesterol (LDL-C) decreased from 3.7 (±1.0) to 3.3 (±0.9)mmol/L (P=0.010). In the PTX group, the Total-C and LDL-C remained unchanged resulting in a significant between-group difference over time (P=0.013 and P=0.026, respectively). This difference was driven by patients who started with lipid-lowering medication during the study period (OBS: 5; PTX: 1). There was an increase in trunk fat mass in the OBS group, but no between-group differences over time. Mean 25(OH) vitamin D increased in the PTX group (P<0.001), but did not change in the OBS group. No difference in parameters of glucose metabolism was detected.In mild PHPT, the measured metabolic and cardiovascular risk factors were not modified by PTX. Observation seems safe and cardiovascular risk reduction should not be regarded as a separate indication for parathyroidectomy based on the results from this study.

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  • Lundstam, KarolinaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology(Swepub:gu)xlunks (author)
  • Mollerup, Charlotte (author)
  • Fougner, Fougner (author)
  • Pernow, YlvaKarolinska Institutet (author)
  • Nordenström, JörgenKarolinska Institutet (author)
  • Rosén, Thord,1949 (author)
  • Jansson, Svante,1948 (author)
  • Hellström, Mikael,1950Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology(Swepub:gu)xhelmi (author)
  • Bollerslev, Jens (author)
  • Heck, Ansgar (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiologi (creator_code:org_t)

Related titles

  • In:Endocrine connections7:8, s. 941-9482049-3614

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