Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer.

Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer.Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient-specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre-treatment blood samples and longitudinally during standard follow-up. Circulating tumor DNA status during follow-up was correlated to disease recurrence.Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence.Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies.

Sridhar, Praveen (author)
Devaiah, Anand (author)
Yamada, Emiko (author)
Saunders, Stefanie (author)
Ståhlberg, Anders,1975Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xsandw (author)
Filges, Stefan,1991Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xfilst (author)
Krzyzanowski, Paul M (author)
Kalatskaya, Irina (author)
Jiao, Wei (author)
Stein, Lincoln D (author)
Jalisi, Scharukh (author)
Godfrey, Tony E (author)
Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)

By the author/editor: Egyud, Matthew; Sridhar, Praveen; Devaiah, Anand; Yamada, Emiko; Saunders, Stefan ...; Ståhlberg, Ander ...; show more...; Filges, Stefan, ...; Krzyzanowski, Pa ...; Kalatskaya, Irin ...; Jiao, Wei; Stein, Lincoln D; Jalisi, Scharukh; Godfrey, Tony E; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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