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Interplay between g...
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Li, Sherly XUniversity of Cambridge
(author)
Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-03-17
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/276421
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https://gup.ub.gu.se/publication/276421URI
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https://doi.org/10.1007/s00125-018-4586-2DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147799URI
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https://lup.lub.lu.se/record/6b7e9f29-6f58-415c-9c6b-0c5518951b30URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes.We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N=21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution.No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined.Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Imamura, FumiakiUniversity of Cambridge
(author)
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Schulze, Matthias BGerman Institute of Human Nutrition,German Center for Diabetes Research
(author)
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Zheng, JushengUniversity of Cambridge
(author)
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Ye, ZhengUniversity of Cambridge
(author)
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Agudo, AntonioCatalan Institute of Oncology,University of Cambridge
(author)
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Ardanaz, EvaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05
(author)
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Aune, DagfinnBjørknes University College,Imperial College London
(author)
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Boeing, HeinerGerman Institute of Human Nutrition
(author)
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Dorronsoro, MirenBiodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP),Public Health Division of Gipuzkoa
(author)
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Dow, CourtneyUniversity of Paris-Saclay,Versailles Saint-Quentin-en-Yvelines University
(author)
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Fagherazzi, GuyVersailles Saint-Quentin-en-Yvelines University,University of Paris-Saclay
(author)
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Grioni, SaraIstituto Nazionale dei Tumori
(author)
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Gunter, Marc JInternational Agency for Research on Cancer, World Health Organization
(author)
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Huerta, José MaríaMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Ibsen, Daniel BAarhus University
(author)
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Jakobsen, Marianne UhreAarhus University,Technical University of Denmark
(author)
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Kaaks, RudolfGerman Cancer Research Centre
(author)
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Key, Timothy JUniversity of Oxford
(author)
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Khaw, Kay-TeeUniversity of Cambridge
(author)
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Kyrø, CecilieDanish Cancer Society
(author)
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Mancini, Francesca RomanaVersailles Saint-Quentin-en-Yvelines University,University of Paris-Saclay
(author)
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Molina-Portillo, ElenaCIBER Epidemiology and Public Health (CIBERESP),University of Granada
(author)
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Murphy, NeilInternational Agency for Research on Cancer, World Health Organization
(author)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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Onland-Moret, N CharlotteUniversity Medical Center Utrecht
(author)
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Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(author)
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Panico, SalvatoreUniversity of Naples Federico II
(author)
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Poveda, AlaitzUmeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för omvårdnad,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-azp
(author)
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Quirós, J RamónPublic Health Directorate
(author)
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Ricceri, FulvioUniversity of Turin
(author)
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Sluijs, IvonneUniversity Medical Center Utrecht
(author)
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Spijkerman, Annemieke M WNational Institute for Public Health and the Environment (RIVM)
(author)
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Tjonneland, AnneDanish Cancer Society
(author)
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Tumino, RosarioCivic and M.P Arezzo Hospital,Associazione Iblea per la Ricerca Epidemiologica
(author)
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Winkvist, Anna,1962University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xwinan
(author)
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Langenberg, ClaudiaUniversity of Cambridge
(author)
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Sharp, Stephen JUniversity of Cambridge
(author)
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Riboli, ElioImperial College London
(author)
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Scott, Robert A
(author)
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Forouhi, Nita GUniversity of Cambridge
(author)
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Wareham, Nicholas JUniversity of Cambridge
(author)
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University of CambridgeGerman Institute of Human Nutrition
(creator_code:org_t)
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In:Diabetologia: Springer Science and Business Media LLC61:6, s. 1325-13321432-04280012-186X
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- By the author/editor
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Li, Sherly X
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Imamura, Fumiaki
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Schulze, Matthia ...
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Zheng, Jusheng
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Ye, Zheng
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Agudo, Antonio
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Ardanaz, Eva
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Aune, Dagfinn
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Boeing, Heiner
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Dorronsoro, Mire ...
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Dow, Courtney
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Fagherazzi, Guy
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Grioni, Sara
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Gunter, Marc J
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Huerta, José Mar ...
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Ibsen, Daniel B
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Jakobsen, Marian ...
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Kaaks, Rudolf
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Key, Timothy J
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Khaw, Kay-Tee
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Kyrø, Cecilie
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Mancini, Frances ...
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Molina-Portillo, ...
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Murphy, Neil
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Nilsson, Peter M ...
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Onland-Moret, N ...
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Palli, Domenico
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Panico, Salvator ...
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Poveda, Alaitz
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Quirós, J Ramón
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Ricceri, Fulvio
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Sluijs, Ivonne
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tumino, Rosario
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Winkvist, Anna, ...
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Langenberg, Clau ...
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Sharp, Stephen J
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Riboli, Elio
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Scott, Robert A
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Forouhi, Nita G
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Diabetologia
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University of Gothenburg
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Umeå University
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Lund University