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Unexplored therapeu...
Unexplored therapeutic opportunities in the human genome
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- Oprea, Tudor I (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Bologa, C. G. (author)
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Brunak, S. (author)
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Campbell, A. (author)
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Gan, G. N. (author)
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Gaulton, A. (author)
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Gomez, S. M. (author)
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Guha, R. (author)
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Hersey, A. (author)
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Holmes, J. (author)
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Jadhav, A. (author)
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Jensen, L. J. (author)
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Johnson, G. L. (author)
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Karlson, A. (author)
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Leach, A. R. (author)
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Ma'ayan, A. (author)
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Malovannaya, A. (author)
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Mani, S. (author)
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Mathias, S. L. (author)
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McManus, M. T. (author)
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Meehan, T. F. (author)
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von Mering, C. (author)
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Muthas, D. (author)
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Nguyen, D. T. (author)
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Overington, J. P. (author)
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Papadatos, G. (author)
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Qin, J. (author)
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Reich, C. (author)
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Roth, B. L. (author)
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Schurer, S. C. (author)
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Simeonov, A. (author)
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Sklar, L. A. (author)
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Southall, N. (author)
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Tomita, S. (author)
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Tudose, I. (author)
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Ursu, O. (author)
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Vidovic, D. (author)
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Waller, A. (author)
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Westergaard, D. (author)
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Yang, J. J. (author)
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Zahoranszky-Kohalmi, G. (author)
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(creator_code:org_t)
- 2018-03-23
- 2018
- English.
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In: Nature Reviews Drug Discovery. - : Springer Science and Business Media LLC. - 1474-1776 .- 1474-1784. ; 17:5, s. 317-332
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Abstract
Subject headings
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- A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- orphan nuclear receptors
- drug discovery
- target identification
- genetic
- association
- protein-degradation
- druggable genome
- large-scale
- ligands
- schizophrenia
- expression
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Oprea, Tudor I
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Bologa, C. G.
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Brunak, S.
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Campbell, A.
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Gan, G. N.
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Gaulton, A.
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show more...
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Gomez, S. M.
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Guha, R.
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Hersey, A.
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Holmes, J.
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Jadhav, A.
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Jensen, L. J.
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Johnson, G. L.
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Karlson, A.
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Leach, A. R.
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Ma'ayan, A.
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Malovannaya, A.
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Mani, S.
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Mathias, S. L.
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McManus, M. T.
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Meehan, T. F.
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von Mering, C.
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Muthas, D.
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Nguyen, D. T.
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Overington, J. P ...
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Papadatos, G.
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Qin, J.
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Reich, C.
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Roth, B. L.
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Schurer, S. C.
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Simeonov, A.
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Sklar, L. A.
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Southall, N.
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Tomita, S.
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Tudose, I.
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Ursu, O.
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Vidovic, D.
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Waller, A.
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Westergaard, D.
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Yang, J. J.
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Zahoranszky-Koha ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Reviews D ...
- By the university
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University of Gothenburg