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Highly modified and...
Highly modified and immunoactive N-glycans of the canine heartworm
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Martini, F. (author)
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Eckmair, B. (author)
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Stefanic, S. (author)
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- Jin, Chunsheng (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Garg, M. (author)
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Yan, S. (author)
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Jimenez-Castells, C. (author)
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Hykollari, A. (author)
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Neupert, C. (author)
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Venco, L. (author)
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Silva, D. V. (author)
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Wilson, I. B. H. (author)
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Paschinger, K. (author)
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(creator_code:org_t)
- 2019-01-08
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Abstract
Subject headings
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- The canine heartworm (Dirofilaria immitis) is a mosquito-borne parasitic nematode whose range is extending due to climate change. In a four-dimensional analysis involving HPLC, MALDI-TOF-MS and MS/MS in combination with chemical and enzymatic digestions, we here reveal an N-glycome of unprecedented complexity. We detect N-glycans of up to 7000 Da, which contain long fucosylated HexNAc-based repeats, as well as glucuronylated structures. While some modifications including LacdiNAc, chitobiose, alpha 1,3-fucose and phosphorylcholine are familiar, anionic N-glycans have previously not been reported in nematodes. Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antennal fucose and phosphorylcholine residues are removed; this pattern of reactivity is reversed for mammalian C-reactive protein, which can in turn be bound by the complement component C1q. Thereby, the N-glycans of D. immitis contain features which may either mediate immunomodulation of the host or confer the ability to avoid immune surveillance. RAHAM D, 1991, JOURNAL OF PARASITOLOGY, V77, P254
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- c-reactive protein
- dirofilaria-immitis
- schistosoma-mansoni
- linked
- oligosaccharides
- symbol nomenclature
- protective immunity
- parasitic
- helminths
- important epitope
- o-glycans
- phosphorylcholine
- Science & Technology - Other Topics
- ott al
- 1988
- experimental parasitology
- v67
- p307
- otocols
- v1503
- p167
- ates of america
- v110
- pe2209
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Martini, F.
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Eckmair, B.
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Stefanic, S.
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Jin, Chunsheng
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Garg, M.
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Yan, S.
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show more...
-
Jimenez-Castells ...
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Hykollari, A.
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Neupert, C.
-
Venco, L.
-
Silva, D. V.
-
Wilson, I. B. H.
-
Paschinger, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg