Search: onr:"swepub:oai:gup.ub.gu.se/277354" >
Melatonin receptor ...
Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway
-
Wang, J. M. (author)
-
Jiang, C. (author)
-
Zhang, K. (author)
-
show more...
-
Lan, X. (author)
-
Chen, X. M. (author)
-
Zang, W. D. (author)
-
Wang, Z. Y. (author)
-
Guan, F. X. (author)
-
- Zhu, Changlian, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
Yang, X. L. (author)
-
Lu, H. (author)
-
Wang, J. (author)
-
N A, Jove J. Vis Exp Jan (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Free Radical Biology and Medicine. - : Elsevier BV. - 0891-5849. ; 131, s. 345-355
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin, a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant properties. In this study, using a weight-drop model of TBI, we investigated the protective effects of ramelteon, a melatonin MT1/MT2 receptor agonist, and its underlying mechanisms of action. Administration of ramelteon (10 mg/kg) daily at 10:00 a.m. alleviated TBI-induced early brain damage on day 3 and long-term neurobehavioral deficits on day 28 in C57BL/6 mice. Ramelteon also increased the protein levels of interleukin (IL)-10, IL-4, superoxide dismutase (SOD), glutathione, and glutathione peroxidase and reduced the protein levels of IL-1 beta, tumor necrosis factor, and malondialdehyde in brain tissue and serum on days 1, 3, and 7 post-TBI. Similarly, ramelteon attenuated microglial and astrocyte activation in the perilesional cortex on day 3. Furthermore, ramelteon decreased Keap 1 expression, promoted nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear accumulation, and increased levels of downstream proteins, including SOD-1, heme oxygenase-1, and NQO1 on day 3 post-TBI. However, in Nrf2 knockout mice with TBI, ramelteon did not decrease the lesion volume, neuronal degeneration, or myelin loss on day 3; nor did it mitigate depression-like behavior or most motor behavior deficits on day 28. Thus, timed ramelteon treatment appears to prevent inflammation and oxidative stress via the Nrf2-antioxidant response element pathway and might represent a potential chronotherapeutic strategy for treating TBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Chronotherapy
- Inflammation
- NF-E2-related factor
- Oxidative stress
- Ramelteon
- Traumatic brain
- mononuclear-cell transplantation
- intracerebral hemorrhage
- rat model
- possible involvement
- ramelteon tak-375
- up-regulation
- neuroinflammation
- neuroprotection
- agonist
- sleep
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- ates of america
- v107
- p6412
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wang, J. M.
-
Jiang, C.
-
Zhang, K.
-
Lan, X.
-
Chen, X. M.
-
Zang, W. D.
-
show more...
-
Wang, Z. Y.
-
Guan, F. X.
-
Zhu, Changlian, ...
-
Yang, X. L.
-
Lu, H.
-
Wang, J.
-
N A, Jove J. Vis ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Free Radical Bio ...
- By the university
-
University of Gothenburg