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A Randomized Trial ...
A Randomized Trial of Endometrial Scratching before In Vitro Fertilization
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Lensen, S. (author)
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Osavlyuk, D. (author)
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Armstrong, S. (author)
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- Stadelmann, Caroline (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Hennes, A. (author)
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Napier, E. (author)
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Wilkinson, J. (author)
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Sadler, L. (author)
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Gupta, D. (author)
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- Strandell, Annika, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Bergh, Christina, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Vigneswaran, K. (author)
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Teh, W. T. (author)
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Hamoda, H. (author)
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Webber, L. (author)
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Wakeman, S. A. (author)
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Searle, L. (author)
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Bhide, P. (author)
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McDowell, S. (author)
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Peeraer, K. (author)
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Khalaf, Y. (author)
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Farquhar, C. (author)
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: New England Journal of Medicine. - 0028-4793. ; 380:4, s. 325-334
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF). We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysteroscopy). Participants were randomly assigned in a 1: 1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle) or no intervention. The primary outcome was live birth. A total of 1364 women underwent randomization. The frequency of live birth was 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the control group (adjusted odds ratio, 1.00; 95% confidence interval, 0.78 to 1.27). There were no significant between-group differences in the rates of ongoing pregnancy, clinical pregnancy, multiple pregnancy, ectopic pregnancy, or miscarriage. The median score for pain from endometrial scratching (on a scale of 0 to 10, with higher scores indicating worse pain) was 3.5 (interquartile range, 1.9 to 6.0). Endometrial scratching did not result in a higher rate of live birth than no intervention among women undergoing IVF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- live-birth-rates
- pregnancy rate
- implantation failure
- embryo-transfer
- injury
- women
- metaanalyses
- inflammation
- infertility
- outcomes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lensen, S.
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Osavlyuk, D.
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Armstrong, S.
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Stadelmann, Caro ...
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Hennes, A.
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Napier, E.
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show more...
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Wilkinson, J.
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Sadler, L.
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Gupta, D.
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Strandell, Annik ...
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Bergh, Christina ...
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Vigneswaran, K.
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Teh, W. T.
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Hamoda, H.
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Webber, L.
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Wakeman, S. A.
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Searle, L.
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Bhide, P.
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McDowell, S.
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Peeraer, K.
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Khalaf, Y.
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Farquhar, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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New England Jour ...
- By the university
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University of Gothenburg