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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008016naa a2200781 4500
001oai:gup.ub.gu.se/277499
003SwePub
008240528s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-375854
009oai:DiVA.org:liu-154120
009oai:DiVA.org:his-16633
009oai:prod.swepub.kib.ki.se:140045754
009oai:lup.lub.lu.se:094ad7c4-0407-4555-9470-71f4d239228b
0247 a https://gup.ub.gu.se/publication/2774992 URI
0247 a https://doi.org/10.1210/jc.2018-009352 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3758542 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1541202 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-166332 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1400457542 URI
0247 a https://lup.lub.lu.se/record/094ad7c4-0407-4555-9470-71f4d239228b2 URI
040 a (SwePub)gud (SwePub)uud (SwePub)liud (SwePub)hisd (SwePub)kid (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nilsson, Emmau Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-eca
2451 0a Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary Syndrome
264 c 2018-08-02
264 1b The Endocrine Society,c 2018
500 a Funding Agencies|Swedish Medical Research Council [2014-2775, 2016-02486]; Jane and Dan Ohlsson Foundation; Adlerbert Research Foundation; Novo Nordisk Foundation [NNF17OC002672]; Strategic Research Programme in Diabetes at Karolinska Institutet; Stockholm County Council; Karolinska Institutet
500 a Copyright © 2018 Endocrine Society
520 a Context: Insulin resistance in skeletal muscle is a major risk factor for the development of type 2 diabetes in women with polycystic ovary syndrome (PCOS). Despite this, the mechanisms underlying insulin resistance in PCOS are largely unknown. Objective: To investigate the genome-wide DNA methylation and gene expression patterns in skeletal muscle from women with PCOS and controls and relate them to phenotypic variations. Design/Participants: In a case-control study, skeletal muscle biopsies from women with PCOS (n = 17) and age-, weight-, and body mass index. matched controls (n = 14) were analyzed by array-based DNA methylation and mRNA expression profiling. Results: Eighty-five unique transcripts were differentially expressed in muscle from women with PCOS vs controls, including DYRK1A, SYNPO2, SCP2, and NAMPT. Furthermore, women with PCOS had reduced expression of genes involved in immune system pathways. Two CpG sites showed differential DNA methylation after correction for multiple testing. However, an mRNA expression of similar to 30% of the differentially expressed genes correlated with DNA methylation levels of CpG sites in or near the gene. Functional follow-up studies demonstrated that KLF10 is under transcriptional control of insulin, where insulin promotes glycogen accumulation in myotubes of human muscle cells. Testosterone downregulates the expression levels of COL1A1 and MAP2K6. Conclusion: PCOS is associated with aberrant skeletal muscle gene expression with dysregulated pathways. Furthermore, we identified specific changes in muscle DNA methylation that may affect gene expression. This study showed that women with PCOS have epigenetic and transcriptional changes in skeletal muscle that, in part, can explain the metabolic abnormalities seen in these women.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a human adipose-tissue
653 a hla-g
653 a glucose-metabolism
653 a insulin-resistance
653 a glycogen-synthase
653 a DNA methylation
653 a human myotubes
653 a expression
653 a phosphorylation
653 a klf10
653 a Endocrinology & Metabolism
653 a Translationell medicin TRIM
7001 a Benrick, Anna,d 1979u University of Skövde,University of Gothenburg,Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden; Univ Skövde, Sch Hlth & Educ, Skövde, Sweden,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Translationell medicin (TRIM), Translational Medicine4 aut0 (Swepub:his)benb
7001 a Kokosar, Milanau University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden,Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xkokom
7001 a Krook, A.u Karolinska Institutet4 aut
7001 a Lindgren, E.u Karolinska Institutet4 aut
7001 a Källman, Thomas,d 1976-u Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Natl Bioinformat Infrastruct Sweden, Uppsala, Sweden,Department of Medical Biochemistry and Microbiology, National Bioinformatics Infrastructure Sweden, SciLifeLab, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)thkal021
7001 a Martis-Thiele, Mihaela-Mariau Linköping University,Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,National Bioinformatics Infrastructure Sweden, Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)mihma11
7001 a Hojlund, K.u Odense Univ, Dept Endocrinol, Odense C, Denmark,Department of Endocrinology, Odense University, Odense C, Denmark,University of Southern Denmark4 aut
7001 a Ling, Charlotteu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-cl0
7001 a Stener-Victorin, E.u Karolinska Institutet4 aut
7102 a Diabetes - epigenetikb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Clinical Endocrinology & Metabolismd : The Endocrine Societyg 103:12, s. 4465-4477q 103:12<4465-4477x 0021-972Xx 1945-7197
8564 u https://academic.oup.com/jcem/article-pdf/103/12/4465/26332867/jc.2018-00935.pdf
8564 u http://dx.doi.org/10.1210/jc.2018-00935y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/277499
8564 8u https://doi.org/10.1210/jc.2018-00935
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-375854
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154120
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16633
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140045754
8564 8u https://lup.lub.lu.se/record/094ad7c4-0407-4555-9470-71f4d239228b

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