Search: onr:"swepub:oai:gup.ub.gu.se/278536" > Cardiovascular Risk...
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000 | 22464naa a2202545 4500 | |
001 | oai:gup.ub.gu.se/278536 | |
003 | SwePub | |
008 | 240910s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-379278 | |
009 | oai:lup.lub.lu.se:2d7aa184-c3a6-4b3a-bd4a-1ae8d130e811 | |
024 | 7 | a https://gup.ub.gu.se/publication/2785362 URI |
024 | 7 | a https://doi.org/10.1001/jamacardio.2018.45372 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3792782 URI |
024 | 7 | a https://lup.lub.lu.se/record/2d7aa184-c3a6-4b3a-bd4a-1ae8d130e8112 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gregson, J.u London Sch Hyg & Trop Med, London, England,Erasmus MC, Rotterdam, Netherlands,London School of Hygiene and Tropical Medicine4 aut |
245 | 1 0 | a Cardiovascular Risk Factors Associated With Venous Thromboembolism |
264 | 1 | b American Medical Association (AMA),c 2019 |
520 | a IMPORTANCE It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE). OBJECTIVE To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism. DESIGN, SETTING, AND PARTICIPANTS This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Participants without cardiovascular disease at baseline were included. Data were analyzed from June 2017 to September 2018. MAIN OUTCOMES AND MEASURES Hazard ratios (HRs) per 1-SD higher usual risk factor levels (or presence/absence). Incident fatal outcomes in ERFC (VTE, 1041; coronary heart disease [CND], 25131) and incident fatal/nonfatal outcomes in UK Biobank (VTE, 2321; CHD, 3385). Hazard ratios were adjusted for age, sex, smoking status, diabetes, and body mass index (BMI). RESULTS Of the 731728 participants from the ERFC. 403 396 (55.1%) were female, and the mean (SD) age at the time of the survey was 51.9 (9.0) years; of the 421537 participants from the UK Biobank, 233 699 (55.4%) were female, and the mean (SD) age at the time of the survey was 56.4 (8.1) years. Risk factors for VTE included older age (ERFC: HR per decade, 2.67; 95% CI, 2.45-2.91; UK Biobank: HR, 1.81; 95% CI, 1.71-1.92), current smoking (ERFC: HR, 1.38; 95% CI, 1.20-1.58; UK Biobank: HR, 1.23; 95% CI, 1.08-1.40), and BMI (ERFC: HR per 1-SD higher BMI, 1.43; 95% CI, 1.35-1.50; UK Biobank: HR, 1.37; 95% CI, 1.32-1.41). For these factors, there were similar HRs for pulmonary embolism and deep vein thrombosis in UK Biobank (except adiposity was more strongly associated with pulmonary embolism) and similar HRs for unprovoked vs provoked VTE. Apart from adiposity, these risk factors were less strongly associated with VTE than CHD. There were inconsistent associations of VTEs with diabetes and blood pressure across ERFC and UK Biobank, and there was limited ability to study lipid and inflammation markers. CONCLUSIONS AND RELEVANCE Older age, smoking, and adiposity were consistently associated with higher VTE risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a individual-participant data | |
653 | a coronary-heart-disease | |
653 | a deep-vein | |
653 | a thrombosis | |
653 | a alcohol-consumption | |
653 | a pulmonary-embolism | |
653 | a diabetes-mellitus | |
653 | a smoking | |
653 | a obesity | |
653 | a metaanalysis | |
653 | a lipoprotein | |
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700 | 1 | a Bolton, T.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Univ Cambridge, NIH, Res Blood & Transplant Res Unit Donor Hlth & Geno, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England4 aut |
700 | 1 | a Pennells, L.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England4 aut |
700 | 1 | a Willeit, P.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Med Univ Innsbruck, Innsbruck, Austria4 aut |
700 | 1 | a Burgess, S.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Univ Cambridge, MRC Biostat Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England4 aut |
700 | 1 | a Bell, S.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Univ Cambridge, NIH, Res Blood & Transplant Res Unit Donor Hlth & Geno, Cambridge, England4 aut |
700 | 1 | a Sweeting, M.u Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England4 aut |
700 | 1 | a Rimm, E. B.u Harvard TH Chan Sch Publ Hlth, Boston, MA USA4 aut |
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700 | 1 | a Whincup, P. H.u St Georges Univ London, London, England4 aut |
700 | 1 | a Knuiman, M.u Univ Western Australia, Perth, WA, Australia4 aut |
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700 | 1 | a Ninomiya, T.u Kyushu Univ, Fukuoka, Fukuoka, Japan4 aut |
700 | 1 | a Casiglia, E.u Univ Padua, Padua, Italy4 aut |
700 | 1 | a Rodriguez, B.u Univ Hawaii, Honolulu, HI 96822 USA4 aut |
700 | 1 | a Ben-Shlomo, Y.u Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England4 aut |
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700 | 1 | a Simons, L.u Univ New South Wales, Sydney, NSW, Australia4 aut |
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710 | 2 | a London Sch Hyg & Trop Med, London, Englandb Erasmus MC, Rotterdam, Netherlands4 org |
710 | 2 | a Emerging Risk Factors Collaboration |
773 | 0 | t JAMA Cardiologyd : American Medical Association (AMA)g 4:2, s. 163-173q 4:2<163-173x 0965-2590x 2380-6583x 2380-6591 |
856 | 4 | u https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1451&context=sph_facpub |
856 | 4 | u http://dx.doi.org/10.1001/jamacardio.2018.4537y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/278536 |
856 | 4 8 | u https://doi.org/10.1001/jamacardio.2018.4537 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379278 |
856 | 4 8 | u https://lup.lub.lu.se/record/2d7aa184-c3a6-4b3a-bd4a-1ae8d130e811 |
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